iPRESTO: Automated discovery of biosynthetic sub-clusters linked to specific natural product substructures.

Microbial specialised metabolism is full of valuable natural products that are applied clinically, agriculturally, and industrially. The genes that encode their biosynthesis are often physically clustered on the genome in biosynthetic gene clusters (BGCs). Many BGCs consist of multiple groups of co-...

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Bibliographic Details
Main Authors: Joris J R Louwen, Satria A Kautsar, Sven van der Burg, Marnix H Medema, Justin J J van der Hooft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010462