The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening
Current applications of human induced pluripotent stem cell (hiPSC) technologies in patient-specific models of neurodegenerative and neuropsychiatric disorders tend to focus on neuronal phenotypes. Here, we review recent efforts toward advancing hiPSCs toward non-neuronal cell types of the central n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcell.2017.00117/full |
| _version_ | 1818846506027843584 |
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| author | David M. Gonzalez David M. Gonzalez David M. Gonzalez Jill Gregory Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand |
| author_facet | David M. Gonzalez David M. Gonzalez David M. Gonzalez Jill Gregory Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand |
| author_sort | David M. Gonzalez |
| collection | DOAJ |
| description | Current applications of human induced pluripotent stem cell (hiPSC) technologies in patient-specific models of neurodegenerative and neuropsychiatric disorders tend to focus on neuronal phenotypes. Here, we review recent efforts toward advancing hiPSCs toward non-neuronal cell types of the central nervous system (CNS) and highlight their potential use for the development of more complex in vitro models of neurodevelopment and disease. We present evidence from previous works in both rodents and humans of the importance of these cell types (oligodendrocytes, microglia, astrocytes) in neurological disease and highlight new hiPSC-based models that have sought to explore these relationships in vitro. Lastly, we summarize efforts toward conducting high-throughput screening experiments with hiPSCs and propose methods by which new screening platforms could be designed to better capture complex relationships between neural cell populations in health and disease. |
| first_indexed | 2024-12-19T05:46:38Z |
| format | Article |
| id | doaj.art-41a032f0d2f04e29900b15d543ae408a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T05:46:38Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-41a032f0d2f04e29900b15d543ae408a2022-12-21T20:33:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2017-12-01510.3389/fcell.2017.00117323688The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug ScreeningDavid M. Gonzalez0David M. Gonzalez1David M. Gonzalez2Jill Gregory3Kristen J. Brennand4Kristen J. Brennand5Kristen J. Brennand6Kristen J. Brennand7Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Developmental and Stem Cell Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesInstructional Technology Group, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesCurrent applications of human induced pluripotent stem cell (hiPSC) technologies in patient-specific models of neurodegenerative and neuropsychiatric disorders tend to focus on neuronal phenotypes. Here, we review recent efforts toward advancing hiPSCs toward non-neuronal cell types of the central nervous system (CNS) and highlight their potential use for the development of more complex in vitro models of neurodevelopment and disease. We present evidence from previous works in both rodents and humans of the importance of these cell types (oligodendrocytes, microglia, astrocytes) in neurological disease and highlight new hiPSC-based models that have sought to explore these relationships in vitro. Lastly, we summarize efforts toward conducting high-throughput screening experiments with hiPSCs and propose methods by which new screening platforms could be designed to better capture complex relationships between neural cell populations in health and disease.http://journal.frontiersin.org/article/10.3389/fcell.2017.00117/fullhuman induced pluripotent stem cellsdrug screeninggliaschizophreniaALSRett syndrome |
| spellingShingle | David M. Gonzalez David M. Gonzalez David M. Gonzalez Jill Gregory Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand Kristen J. Brennand The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening Frontiers in Cell and Developmental Biology human induced pluripotent stem cells drug screening glia schizophrenia ALS Rett syndrome |
| title | The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening |
| title_full | The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening |
| title_fullStr | The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening |
| title_full_unstemmed | The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening |
| title_short | The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening |
| title_sort | importance of non neuronal cell types in hipsc based disease modeling and drug screening |
| topic | human induced pluripotent stem cells drug screening glia schizophrenia ALS Rett syndrome |
| url | http://journal.frontiersin.org/article/10.3389/fcell.2017.00117/full |
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