The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database
<h4>Background</h4> It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients. <h4>Methods</h4> Critically ill patients with sepsis were identified from the Medical Inf...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907836/?tool=EBI |
| _version_ | 1811167167043862528 |
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| author | Han Chen Shu-Rong Gong Xiu-Ling Shang Jun Li Rong-Guo Yu |
| author_facet | Han Chen Shu-Rong Gong Xiu-Ling Shang Jun Li Rong-Guo Yu |
| author_sort | Han Chen |
| collection | DOAJ |
| description | <h4>Background</h4> It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients. <h4>Methods</h4> Critically ill patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The duration and the magnitude of ECVP were calculated. Normalized ECVP load was defined as the ECVP load (the sum of ECVP value times its duration) divided by the total duration of ECVP. The primary endpoint was 28-day mortality. Kaplan-Meier survival analysis was used to compare survival between patients with high or low normalized ECVP load. <h4>Results</h4> A total of 1071 sepsis patients were included. Higher normalized ECVP load was associated with higher mortality rate; in contrast, the duration of ECVP was not associated with mortality. A linear relationship between normalized ECVP load and mortality was identified. Patients with higher normalized ECVP load had less urine output and more positive fluid balance. <h4>Conclusion</h4> The magnitude, but not the duration of ECVP, is associated with mortality in sepsis patients. ECVP should be considered as a valuable and easily accessible safety parameter during fluid resuscitation. |
| first_indexed | 2024-04-10T16:04:37Z |
| format | Article |
| id | doaj.art-41a06aff5b8440498f928b8c45e602e4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T16:04:37Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-41a06aff5b8440498f928b8c45e602e42023-02-10T05:31:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV databaseHan ChenShu-Rong GongXiu-Ling ShangJun LiRong-Guo Yu<h4>Background</h4> It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients. <h4>Methods</h4> Critically ill patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The duration and the magnitude of ECVP were calculated. Normalized ECVP load was defined as the ECVP load (the sum of ECVP value times its duration) divided by the total duration of ECVP. The primary endpoint was 28-day mortality. Kaplan-Meier survival analysis was used to compare survival between patients with high or low normalized ECVP load. <h4>Results</h4> A total of 1071 sepsis patients were included. Higher normalized ECVP load was associated with higher mortality rate; in contrast, the duration of ECVP was not associated with mortality. A linear relationship between normalized ECVP load and mortality was identified. Patients with higher normalized ECVP load had less urine output and more positive fluid balance. <h4>Conclusion</h4> The magnitude, but not the duration of ECVP, is associated with mortality in sepsis patients. ECVP should be considered as a valuable and easily accessible safety parameter during fluid resuscitation.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907836/?tool=EBI |
| spellingShingle | Han Chen Shu-Rong Gong Xiu-Ling Shang Jun Li Rong-Guo Yu The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database PLoS ONE |
| title | The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database |
| title_full | The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database |
| title_fullStr | The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database |
| title_full_unstemmed | The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database |
| title_short | The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database |
| title_sort | magnitude but not the duration of elevated central venous pressure is associated with mortality in sepsis patients an analysis of the mimic iv database |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907836/?tool=EBI |
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