Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide
Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO<sub>2</sub>)–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron mi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/10/1469 |
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| author | Wahyudiono Jiayang He Xin Hu Siti Machmudah Keiji Yasuda Seiichi Takami Hideki Kanda Motonobu Goto |
| author_facet | Wahyudiono Jiayang He Xin Hu Siti Machmudah Keiji Yasuda Seiichi Takami Hideki Kanda Motonobu Goto |
| author_sort | Wahyudiono |
| collection | DOAJ |
| description | Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO<sub>2</sub>)–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids. |
| first_indexed | 2024-03-10T03:53:59Z |
| format | Article |
| id | doaj.art-41a6d5c5402d48cd992ceb1c64e518e5 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T03:53:59Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-41a6d5c5402d48cd992ceb1c64e518e52023-11-23T10:59:37ZengMDPI AGFoods2304-81582022-05-011110146910.3390/foods11101469Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon DioxideWahyudiono0Jiayang He1Xin Hu2Siti Machmudah3Keiji Yasuda4Seiichi Takami5Hideki Kanda6Motonobu Goto7Department of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Chemical Systems Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanDepartment of Materials Process Engineering, Nagoya University, Nagoya 464-8603, JapanCurcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO<sub>2</sub>)–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.https://www.mdpi.com/2304-8158/11/10/1469supercriticalcurcuminencapsulationliposomephospholipid |
| spellingShingle | Wahyudiono Jiayang He Xin Hu Siti Machmudah Keiji Yasuda Seiichi Takami Hideki Kanda Motonobu Goto Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide Foods supercritical curcumin encapsulation liposome phospholipid |
| title | Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide |
| title_full | Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide |
| title_fullStr | Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide |
| title_full_unstemmed | Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide |
| title_short | Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide |
| title_sort | curcumin loaded liposome preparation in ultrasound environment under pressurized carbon dioxide |
| topic | supercritical curcumin encapsulation liposome phospholipid |
| url | https://www.mdpi.com/2304-8158/11/10/1469 |
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