Retinoic Acid Signalling in the Pineal Gland Is Conserved across Mammalian Species and Its Transcriptional Activity Is Inhibited by Melatonin

Retinoic Acid Signalling in the Pineal Gland Is Conserved across Mammalian Species and Its Transcriptional Activity Is Inhibited by Melatonin

The pineal gland is integral to the circadian timing system due to its role in nightly melatonin production. Retinoic acid (RA) is a potent regulator of gene transcription and has previously been found to exhibit diurnal changes in synthesis and signalling in the rat pineal gland. This study investi...

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Bibliographic Details
Main Authors: Anna Ashton, Jason Clark, Julia Fedo, Angelo Sementilli, Yara D. Fragoso, Peter McCaffery
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
retinoic acid
RAR
RALDH
Rdh10
cyp26a1
circadian
Online Access:https://www.mdpi.com/2073-4409/12/2/286

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