The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement
Parkinson’s disease (PD) is a prevalent neurodegenerative aging disorder that manifests as motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs (ncRNAs). Signal pathway and gene sequence studies have proposed that alteration of ncRNAs is relevant to the occurrence...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/7/811 |
| _version_ | 1797433172252688384 |
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| author | Hanwen Zhang Longping Yao Zijian Zheng Sumeyye Koc Guohui Lu |
| author_facet | Hanwen Zhang Longping Yao Zijian Zheng Sumeyye Koc Guohui Lu |
| author_sort | Hanwen Zhang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a prevalent neurodegenerative aging disorder that manifests as motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs (ncRNAs). Signal pathway and gene sequence studies have proposed that alteration of ncRNAs is relevant to the occurrence and development of PD. Furthermore, many studies on brain tissues and body fluids from patients with PD indicate that variations in ncRNAs and their target genes could trigger or exacerbate neurodegenerative pathogenesis and serve as potential non-invasive biomarkers of PD. Numerous ncRNAs have been considered regulators of apoptosis, α-syn misfolding and aggregation, mitochondrial dysfunction, autophagy, and neuroinflammation in PD etiology, and evidence is mounting for the determination of the role of competing endogenous RNA (ceRNA) mechanisms in disease development. In this review, we discuss the current knowledge regarding the regulation and function of ncRNAs as well as ceRNA networks in PD pathogenesis, focusing on microRNAs, long ncRNAs, and circular RNAs to increase the understanding of the disease and propose potential target identification and treatment in the early stages of PD. |
| first_indexed | 2024-03-09T10:13:16Z |
| format | Article |
| id | doaj.art-41a7fb4897f14fc39d3bdc9a477fdcac |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T10:13:16Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-41a7fb4897f14fc39d3bdc9a477fdcac2023-12-01T22:33:17ZengMDPI AGPharmaceuticals1424-82472022-06-0115781110.3390/ph15070811The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent AdvancementHanwen Zhang0Longping Yao1Zijian Zheng2Sumeyye Koc3Guohui Lu4Department of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaThe Center of Neuroscience, Life Science Zurich Graduate School, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaDepartment of Neuroscience, Institute of Health Sciences, Ondokuz Mayıs University, Samsun 55200, TurkeyDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaParkinson’s disease (PD) is a prevalent neurodegenerative aging disorder that manifests as motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs (ncRNAs). Signal pathway and gene sequence studies have proposed that alteration of ncRNAs is relevant to the occurrence and development of PD. Furthermore, many studies on brain tissues and body fluids from patients with PD indicate that variations in ncRNAs and their target genes could trigger or exacerbate neurodegenerative pathogenesis and serve as potential non-invasive biomarkers of PD. Numerous ncRNAs have been considered regulators of apoptosis, α-syn misfolding and aggregation, mitochondrial dysfunction, autophagy, and neuroinflammation in PD etiology, and evidence is mounting for the determination of the role of competing endogenous RNA (ceRNA) mechanisms in disease development. In this review, we discuss the current knowledge regarding the regulation and function of ncRNAs as well as ceRNA networks in PD pathogenesis, focusing on microRNAs, long ncRNAs, and circular RNAs to increase the understanding of the disease and propose potential target identification and treatment in the early stages of PD.https://www.mdpi.com/1424-8247/15/7/811Parkinson’s diseasenon-coding RNAsneuroinflammationmicrogliadopaminergic neurons |
| spellingShingle | Hanwen Zhang Longping Yao Zijian Zheng Sumeyye Koc Guohui Lu The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement Pharmaceuticals Parkinson’s disease non-coding RNAs neuroinflammation microglia dopaminergic neurons |
| title | The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement |
| title_full | The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement |
| title_fullStr | The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement |
| title_full_unstemmed | The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement |
| title_short | The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement |
| title_sort | role of non coding rnas in the pathogenesis of parkinson s disease recent advancement |
| topic | Parkinson’s disease non-coding RNAs neuroinflammation microglia dopaminergic neurons |
| url | https://www.mdpi.com/1424-8247/15/7/811 |
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