Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital
Background: During the pandemic of COVID-19, phylogenetic changes have been observed in the characteristics of the virus, in the diagnosis and treatment of the disease. The clinical course and the severe form of the disease depends on several factors. This study characterized the beginning setting f...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001563 |
| _version_ | 1818546018086551552 |
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| author | Vanessa da Costa Sousa Mayara Calixto da Silva Matheus Pereira de Mello João Antonio Matheus Guimarães Jamila Alessandra Perini |
| author_facet | Vanessa da Costa Sousa Mayara Calixto da Silva Matheus Pereira de Mello João Antonio Matheus Guimarães Jamila Alessandra Perini |
| author_sort | Vanessa da Costa Sousa |
| collection | DOAJ |
| description | Background: During the pandemic of COVID-19, phylogenetic changes have been observed in the characteristics of the virus, in the diagnosis and treatment of the disease. The clinical course and the severe form of the disease depends on several factors. This study characterized the beginning setting for patient care of COVID-19 in a referral center in one of the main capital cities of Brazil. In addition, were evaluated the factors associated with mortality, length of stay, and diagnostic outcome. Methods: A cross-sectional study was conducted during May 2020 (n = 1100). The association of the variables with outcome was evaluated by a multivariable logistic regression model, using odds ratios (OR) and 95 % confidence intervals (CI). Results: Overall, 76 % of patients were COVID-19 positive, and 70 % were diagnosed by RT–qPCR. The majority were male (56 %), and over 52 years old (74 %), 68 % had hypertension, 44 % had diabetes mellitus, and 32 % were obese. The mean length of stay was 10 ± 8 days, which was higher in the 34 % who died (≥14; OR=2; 95 %CI=1.4–4) and who had hypertension (OR=2; 95 %CI=1.3–3) (P < 0.001). The mean length of stay was also higher (P = 0.008) for those patients with pulmonary impairment ≥ 50 % (10.72 ± 8.24), than those with< 50 % (8.98 ± 6.81). Age (>62 and 65 years) was associated with longer hospitalization (OR=2; 95 %CI=1.4–3) and death (OR=6; 95 %CI=3–11). The time of sample collection for RT–qPCR was different between positive and negative tests (P = 0.001), with the time of 4–10 days showing a greater chance for virus detection (OR=2.9; 95 %CI=1.6–5). Conclusion: Death was associated with age and pulmonary impairment. The length of hospitalization was associated with age, hypertension, pulmonary impairment and death. The time of sample collection to perform RT–qPCR and the rapid test was associated with a positive result for COVID-19. These results highlight the ongoing challenge of diagnosing, treating, and mitigating the effects caused by the COVID-19 pandemic. |
| first_indexed | 2024-12-12T07:47:31Z |
| format | Article |
| id | doaj.art-41a8492d2f14457494ea797d0c50975c |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-12T07:47:31Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-41a8492d2f14457494ea797d0c50975c2022-12-22T00:32:33ZengElsevierJournal of Infection and Public Health1876-03412022-07-01157800805Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospitalVanessa da Costa Sousa0Mayara Calixto da Silva1Matheus Pereira de Mello2João Antonio Matheus Guimarães3Jamila Alessandra Perini4National School of Public Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilNational School of Public Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil; Pharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro, BrazilPharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro, BrazilNational Institute of Traumatology and Orthopaedics (INTO), Research Division of INTO, Rio de Janeiro, RJ, BrazilNational School of Public Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil; Pharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil; National Institute of Traumatology and Orthopaedics (INTO), Research Division of INTO, Rio de Janeiro, RJ, Brazil; Corresponding author at: Pharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.Background: During the pandemic of COVID-19, phylogenetic changes have been observed in the characteristics of the virus, in the diagnosis and treatment of the disease. The clinical course and the severe form of the disease depends on several factors. This study characterized the beginning setting for patient care of COVID-19 in a referral center in one of the main capital cities of Brazil. In addition, were evaluated the factors associated with mortality, length of stay, and diagnostic outcome. Methods: A cross-sectional study was conducted during May 2020 (n = 1100). The association of the variables with outcome was evaluated by a multivariable logistic regression model, using odds ratios (OR) and 95 % confidence intervals (CI). Results: Overall, 76 % of patients were COVID-19 positive, and 70 % were diagnosed by RT–qPCR. The majority were male (56 %), and over 52 years old (74 %), 68 % had hypertension, 44 % had diabetes mellitus, and 32 % were obese. The mean length of stay was 10 ± 8 days, which was higher in the 34 % who died (≥14; OR=2; 95 %CI=1.4–4) and who had hypertension (OR=2; 95 %CI=1.3–3) (P < 0.001). The mean length of stay was also higher (P = 0.008) for those patients with pulmonary impairment ≥ 50 % (10.72 ± 8.24), than those with< 50 % (8.98 ± 6.81). Age (>62 and 65 years) was associated with longer hospitalization (OR=2; 95 %CI=1.4–3) and death (OR=6; 95 %CI=3–11). The time of sample collection for RT–qPCR was different between positive and negative tests (P = 0.001), with the time of 4–10 days showing a greater chance for virus detection (OR=2.9; 95 %CI=1.6–5). Conclusion: Death was associated with age and pulmonary impairment. The length of hospitalization was associated with age, hypertension, pulmonary impairment and death. The time of sample collection to perform RT–qPCR and the rapid test was associated with a positive result for COVID-19. These results highlight the ongoing challenge of diagnosing, treating, and mitigating the effects caused by the COVID-19 pandemic.http://www.sciencedirect.com/science/article/pii/S1876034122001563COVID-19BrazilMortalityDiagnosisRisk factors |
| spellingShingle | Vanessa da Costa Sousa Mayara Calixto da Silva Matheus Pereira de Mello João Antonio Matheus Guimarães Jamila Alessandra Perini Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital Journal of Infection and Public Health COVID-19 Brazil Mortality Diagnosis Risk factors |
| title | Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital |
| title_full | Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital |
| title_fullStr | Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital |
| title_full_unstemmed | Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital |
| title_short | Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital |
| title_sort | factors associated with mortality length of hospital stay and diagnosis of covid 19 data from a field hospital |
| topic | COVID-19 Brazil Mortality Diagnosis Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001563 |
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