BCL7A as a novel prognostic biomarker for glioma patients
Abstract Background Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. BCL7 family has been found in several cancer types and could be involved in tumor progression. While the role of BCL7 family in human glioma has remained to b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-03003-0 |
| _version_ | 1831790933239136256 |
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| author | Junhui Liu Lun Gao Baowei Ji Rongxin Geng Jing Chen Xiang Tao Qiang Cai Zhibiao Chen |
| author_facet | Junhui Liu Lun Gao Baowei Ji Rongxin Geng Jing Chen Xiang Tao Qiang Cai Zhibiao Chen |
| author_sort | Junhui Liu |
| collection | DOAJ |
| description | Abstract Background Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. BCL7 family has been found in several cancer types and could be involved in tumor progression. While the role of BCL7 family in human glioma has remained to be elucidated. Methods Paraffin-embedded tumor samples were obtained to detect BCL7 expression by performing in glioma. Data (including normalized gene expression and corresponding clinical data) were obtained from Gliovis, CGGA, GEO, cBioportal and Oncomine and were used to investigate BCL7 genes expression in glioma. Survival analyses were calculated by Kaplan–Meier methods and Cox regression analysis in TCGA and CGGA. Gene Set Enrichment Analyses (GSEA) and gene ontology (GO) analysis was employed to perform the biological processes enrichment. Results BCL7A expression in glioma tissues was lower compared to non-tumor brain tissues (NBT), and exhibited a negative correlation with glioma grades. Results from immunohistochemical (IHC) staining and public dataset validation demonstrated that BCL7B and BCL7C were highly expressed in glioma tissues compared to NBT. Cox regression analysis identified BCL7A as the only gene in the BCL7 family that was independently associated with the prognosis of lower-grade glioma (LGG) and glioblastoma (GBM). GO and GSEA analyses revealed the potential contribution of BCL7A in adaptive immune response and neutrophil activation in the tumor microenvironment. Moreover, we found that BCL7A had no prognostic effect on the overall survival of GBM patients who received IR only; however, patients who received chemotherapy (TMZ) combined with IR in the high BCL7A group survived longer than patients in the low BCL7A group (HR = 0.346, p < 0.05). Conclusion BCL7A is a new tumor suppressor gene and can be adopted as a biomarker for independent prognosis in glioma and to evaluate response to TMZ. |
| first_indexed | 2024-12-22T14:43:24Z |
| format | Article |
| id | doaj.art-41a84f7846b84e8bbcdadcca5c58e7b8 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-22T14:43:24Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-41a84f7846b84e8bbcdadcca5c58e7b82022-12-21T18:22:30ZengBMCJournal of Translational Medicine1479-58762021-08-0119111610.1186/s12967-021-03003-0BCL7A as a novel prognostic biomarker for glioma patientsJunhui Liu0Lun Gao1Baowei Ji2Rongxin Geng3Jing Chen4Xiang Tao5Qiang Cai6Zhibiao Chen7Department of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityDepartment of Neurosurgery, Renmin Hospital of Wuhan UniversityAbstract Background Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. BCL7 family has been found in several cancer types and could be involved in tumor progression. While the role of BCL7 family in human glioma has remained to be elucidated. Methods Paraffin-embedded tumor samples were obtained to detect BCL7 expression by performing in glioma. Data (including normalized gene expression and corresponding clinical data) were obtained from Gliovis, CGGA, GEO, cBioportal and Oncomine and were used to investigate BCL7 genes expression in glioma. Survival analyses were calculated by Kaplan–Meier methods and Cox regression analysis in TCGA and CGGA. Gene Set Enrichment Analyses (GSEA) and gene ontology (GO) analysis was employed to perform the biological processes enrichment. Results BCL7A expression in glioma tissues was lower compared to non-tumor brain tissues (NBT), and exhibited a negative correlation with glioma grades. Results from immunohistochemical (IHC) staining and public dataset validation demonstrated that BCL7B and BCL7C were highly expressed in glioma tissues compared to NBT. Cox regression analysis identified BCL7A as the only gene in the BCL7 family that was independently associated with the prognosis of lower-grade glioma (LGG) and glioblastoma (GBM). GO and GSEA analyses revealed the potential contribution of BCL7A in adaptive immune response and neutrophil activation in the tumor microenvironment. Moreover, we found that BCL7A had no prognostic effect on the overall survival of GBM patients who received IR only; however, patients who received chemotherapy (TMZ) combined with IR in the high BCL7A group survived longer than patients in the low BCL7A group (HR = 0.346, p < 0.05). Conclusion BCL7A is a new tumor suppressor gene and can be adopted as a biomarker for independent prognosis in glioma and to evaluate response to TMZ.https://doi.org/10.1186/s12967-021-03003-0BCL7 familyGliomaPrognosisImmuneTemozolomide |
| spellingShingle | Junhui Liu Lun Gao Baowei Ji Rongxin Geng Jing Chen Xiang Tao Qiang Cai Zhibiao Chen BCL7A as a novel prognostic biomarker for glioma patients Journal of Translational Medicine BCL7 family Glioma Prognosis Immune Temozolomide |
| title | BCL7A as a novel prognostic biomarker for glioma patients |
| title_full | BCL7A as a novel prognostic biomarker for glioma patients |
| title_fullStr | BCL7A as a novel prognostic biomarker for glioma patients |
| title_full_unstemmed | BCL7A as a novel prognostic biomarker for glioma patients |
| title_short | BCL7A as a novel prognostic biomarker for glioma patients |
| title_sort | bcl7a as a novel prognostic biomarker for glioma patients |
| topic | BCL7 family Glioma Prognosis Immune Temozolomide |
| url | https://doi.org/10.1186/s12967-021-03003-0 |
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