Ion channels as molecular targets of glioblastoma electrotherapy
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1133984/full |
| _version_ | 1827987708851519488 |
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| author | Tayeb Abed Katrin Ganser Franziska Eckert Franziska Eckert Nicolai Stransky Nicolai Stransky Stephan M. Huber |
| author_facet | Tayeb Abed Katrin Ganser Franziska Eckert Franziska Eckert Nicolai Stransky Nicolai Stransky Stephan M. Huber |
| author_sort | Tayeb Abed |
| collection | DOAJ |
| description | Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from direct tumoricidal, radio- or chemotherapy-sensitizing, metastatic spread-inhibiting, up to immunostimulation have been described. Diverse underlying molecular mechanisms, such as dielectrophoresis of cellular compounds during cytokinesis, disturbing the formation of the spindle apparatus during mitosis, and perforating the plasma membrane have been proposed. Little attention, however, has been paid to molecular structures that are predestinated to percept electromagnetic fields—the voltage sensors of voltage-gated ion channels. The present review article briefly summarizes the mode of action of voltage sensing by ion channels. Moreover, it introduces into the perception of ultra-weak electric fields by specific organs of fishes with voltage-gated ion channels as key functional units therein. Finally, this article provides an overview of the published data on modulation of ion channel function by diverse external electromagnetic field protocols. Combined, these data strongly point to a function of voltage-gated ion channels as transducers between electricity and biology and, hence, to voltage-gated ion channels as primary targets of electrotherapy. |
| first_indexed | 2024-04-09T23:52:19Z |
| format | Article |
| id | doaj.art-41a9380da0744cc6925c1195dcb9ceba |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-09T23:52:19Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-41a9380da0744cc6925c1195dcb9ceba2023-03-17T05:34:41ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-03-011710.3389/fncel.2023.11339841133984Ion channels as molecular targets of glioblastoma electrotherapyTayeb Abed0Katrin Ganser1Franziska Eckert2Franziska Eckert3Nicolai Stransky4Nicolai Stransky5Stephan M. Huber6Department of Radiation Oncology, University of Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University of Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University of Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, Medical University Vienna, Vienna, AustriaDepartment of Radiation Oncology, University of Tübingen, Tübingen, GermanyDepartment of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, GermanyDepartment of Radiation Oncology, University of Tübingen, Tübingen, GermanyTherapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from direct tumoricidal, radio- or chemotherapy-sensitizing, metastatic spread-inhibiting, up to immunostimulation have been described. Diverse underlying molecular mechanisms, such as dielectrophoresis of cellular compounds during cytokinesis, disturbing the formation of the spindle apparatus during mitosis, and perforating the plasma membrane have been proposed. Little attention, however, has been paid to molecular structures that are predestinated to percept electromagnetic fields—the voltage sensors of voltage-gated ion channels. The present review article briefly summarizes the mode of action of voltage sensing by ion channels. Moreover, it introduces into the perception of ultra-weak electric fields by specific organs of fishes with voltage-gated ion channels as key functional units therein. Finally, this article provides an overview of the published data on modulation of ion channel function by diverse external electromagnetic field protocols. Combined, these data strongly point to a function of voltage-gated ion channels as transducers between electricity and biology and, hence, to voltage-gated ion channels as primary targets of electrotherapy.https://www.frontiersin.org/articles/10.3389/fncel.2023.1133984/fullalternating electric fieldsEMFelectrolocationampullae of Lorenzinituberous organsvoltage sensor |
| spellingShingle | Tayeb Abed Katrin Ganser Franziska Eckert Franziska Eckert Nicolai Stransky Nicolai Stransky Stephan M. Huber Ion channels as molecular targets of glioblastoma electrotherapy Frontiers in Cellular Neuroscience alternating electric fields EMF electrolocation ampullae of Lorenzini tuberous organs voltage sensor |
| title | Ion channels as molecular targets of glioblastoma electrotherapy |
| title_full | Ion channels as molecular targets of glioblastoma electrotherapy |
| title_fullStr | Ion channels as molecular targets of glioblastoma electrotherapy |
| title_full_unstemmed | Ion channels as molecular targets of glioblastoma electrotherapy |
| title_short | Ion channels as molecular targets of glioblastoma electrotherapy |
| title_sort | ion channels as molecular targets of glioblastoma electrotherapy |
| topic | alternating electric fields EMF electrolocation ampullae of Lorenzini tuberous organs voltage sensor |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1133984/full |
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