Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis.
In mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3930584?pdf=render |
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| author | Hironori Abe Mohamad Omar Al-zi'abi Fumio Sekizawa Tomas J Acosta Dariusz J Skarzynski Kiyoshi Okuda |
| author_facet | Hironori Abe Mohamad Omar Al-zi'abi Fumio Sekizawa Tomas J Acosta Dariusz J Skarzynski Kiyoshi Okuda |
| author_sort | Hironori Abe |
| collection | DOAJ |
| description | In mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transported from the ovary via lymphatic vessels. Here, we report the presence of cells positive for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme involved in progesterone synthesis, in the lumen of lymphatic vessels at the regressing luteal stage and in the lymphatic fluid collected from the ovarian pedicle ipsilateral to the regressing CL. The 3β-HSD positive cells were alive and contained lipid droplets. The 3β-HSD positive cells in the lymphatic fluid were most abundant at days 22-24 after ovulation. These findings show that live steroidogenic cells are in the lymphatic vessels drained from the CL. The outflow of steroidogenic cells starts at the regressing luteal stage and continues after next ovulation. The overall findings suggest that the complete disappearance of the CL during luteolysis is involved in the outflow of luteal cells from the CL via ovarian lymphatic vessels. |
| first_indexed | 2024-12-21T15:54:49Z |
| format | Article |
| id | doaj.art-41a95861e8da4dd19446d50703b6dd0d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:54:49Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-41a95861e8da4dd19446d50703b6dd0d2022-12-21T18:58:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8895310.1371/journal.pone.0088953Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis.Hironori AbeMohamad Omar Al-zi'abiFumio SekizawaTomas J AcostaDariusz J SkarzynskiKiyoshi OkudaIn mammals, the corpus luteum (CL) is an essential endocrine gland for the establishment and maintenance of pregnancy. If pregnancy is not established, the CL regresses and disappears rapidly from the ovary. A possible explanation for the rapid disappearance of the CL is that luteal cells are transported from the ovary via lymphatic vessels. Here, we report the presence of cells positive for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme involved in progesterone synthesis, in the lumen of lymphatic vessels at the regressing luteal stage and in the lymphatic fluid collected from the ovarian pedicle ipsilateral to the regressing CL. The 3β-HSD positive cells were alive and contained lipid droplets. The 3β-HSD positive cells in the lymphatic fluid were most abundant at days 22-24 after ovulation. These findings show that live steroidogenic cells are in the lymphatic vessels drained from the CL. The outflow of steroidogenic cells starts at the regressing luteal stage and continues after next ovulation. The overall findings suggest that the complete disappearance of the CL during luteolysis is involved in the outflow of luteal cells from the CL via ovarian lymphatic vessels.http://europepmc.org/articles/PMC3930584?pdf=render |
| spellingShingle | Hironori Abe Mohamad Omar Al-zi'abi Fumio Sekizawa Tomas J Acosta Dariusz J Skarzynski Kiyoshi Okuda Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. PLoS ONE |
| title | Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. |
| title_full | Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. |
| title_fullStr | Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. |
| title_full_unstemmed | Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. |
| title_short | Lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis. |
| title_sort | lymphatic involvement in the disappearance of steroidogenic cells from the corpus luteum during luteolysis |
| url | http://europepmc.org/articles/PMC3930584?pdf=render |
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