Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis
For a better understanding of the pathophysiology of spondyloarthropathy (SpA), a detailed anatomical description of the sacroiliac joint is required because sacroiliitis is the earliest and most common sign of SpA and an essential feature for the diagnosis of ankylosing spondylitis. Beyond the anat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1182902/full |
| _version_ | 1797828855183966208 |
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| author | Clément Prati Thierry Lequerre Benoît Le Goff Bernard Cortet Hechmi Toumi Anne Tournadre Hubert Marotte Eric Lespessailles |
| author_facet | Clément Prati Thierry Lequerre Benoît Le Goff Bernard Cortet Hechmi Toumi Anne Tournadre Hubert Marotte Eric Lespessailles |
| author_sort | Clément Prati |
| collection | DOAJ |
| description | For a better understanding of the pathophysiology of spondyloarthropathy (SpA), a detailed anatomical description of the sacroiliac joint is required because sacroiliitis is the earliest and most common sign of SpA and an essential feature for the diagnosis of ankylosing spondylitis. Beyond the anatomy, the histopathology of sacroiliac entheses and immunological mechanisms involved in sacroiliitis are crucial for a better understanding of disease causation. In this narrative review, we discuss the core anatomical, histological, and immunohistological observations involved in the development of sacroiliitis, focusing particularly on imaging-based information associated with sacroiliitis. Finally, we try to answer the question of whether at the sacroiliac joint, enthesitis precedes synovitis and subchondral bone changes in SpA. |
| first_indexed | 2024-04-09T13:11:04Z |
| format | Article |
| id | doaj.art-41a96a43473b491c83935ec26ef28526 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T13:11:04Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-41a96a43473b491c83935ec26ef285262023-05-12T07:00:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-05-011410.3389/fphys.2023.11829021182902Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritisClément Prati0Thierry Lequerre1Benoît Le Goff2Bernard Cortet3Hechmi Toumi4Anne Tournadre5Hubert Marotte6Eric Lespessailles7Department of Rheumatology, Besançon University Hospital, PEPITE EA4267, University of Franche-Comté, Besançon, FranceDepartment of Rheumatology, Rouen University Hospital, Inserm 1234, CIC/CRB 1404, Rouen, FranceDepartment of Rheumatology—CHU de Nantes, Nantes, FranceDepartment of Rheumatology, MABLAB ULR 4490, CHU Lille, University Lille, Lille, FranceDepartment of Rheumatology, Translational Medicine Research Platform, PRIMMO, University Hospital Center of Orleans, Orleans, FranceDepartment of Rheumatology, CHU Clermont-Ferrand, UNH UMR1019 INRAE–Université Clermont Auvergne, Clermont-Ferrand, FranceDepartment of Rheumatology, University Hospital of Saint Etienne, INSERM, SAINBIOSE U1059, Saint-Etienne, FranceDepartment of Rheumatology, Translational Medicine Research Platform, PRIMMO, University Hospital Center of Orleans, Orleans, FranceFor a better understanding of the pathophysiology of spondyloarthropathy (SpA), a detailed anatomical description of the sacroiliac joint is required because sacroiliitis is the earliest and most common sign of SpA and an essential feature for the diagnosis of ankylosing spondylitis. Beyond the anatomy, the histopathology of sacroiliac entheses and immunological mechanisms involved in sacroiliitis are crucial for a better understanding of disease causation. In this narrative review, we discuss the core anatomical, histological, and immunohistological observations involved in the development of sacroiliitis, focusing particularly on imaging-based information associated with sacroiliitis. Finally, we try to answer the question of whether at the sacroiliac joint, enthesitis precedes synovitis and subchondral bone changes in SpA.https://www.frontiersin.org/articles/10.3389/fphys.2023.1182902/fullspondyloarthropathyenthesitisankylosing spondylitisimmunometabolismstructural progressionsacroiliac joint |
| spellingShingle | Clément Prati Thierry Lequerre Benoît Le Goff Bernard Cortet Hechmi Toumi Anne Tournadre Hubert Marotte Eric Lespessailles Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis Frontiers in Physiology spondyloarthropathy enthesitis ankylosing spondylitis immunometabolism structural progression sacroiliac joint |
| title | Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| title_full | Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| title_fullStr | Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| title_full_unstemmed | Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| title_short | Novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| title_sort | novel insights into the anatomy and histopathology of the sacroiliac joint and correlations with imaging signs of sacroiliitis in case of axial spondyloarthritis |
| topic | spondyloarthropathy enthesitis ankylosing spondylitis immunometabolism structural progression sacroiliac joint |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1182902/full |
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