Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix
Intraventricular hemorrhage (IVH) is one of the most critical complications in the development of preterm infants. The likelihood of IVH is strongly associated with disturbances in cerebral blood flow (CBF) and with microvascular fragility in the germinal matrix (GM). The CBF value and its reactivit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00812/full |
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| author | Irina Sidorenko Varvara Turova Nikolai Botkin Laura Eckardt Ana Alves-Pinto Ursula Felderhoff-Müser Esther Rieger-Fackeldey Andrey Kovtanyuk Renée Lampe |
| author_facet | Irina Sidorenko Varvara Turova Nikolai Botkin Laura Eckardt Ana Alves-Pinto Ursula Felderhoff-Müser Esther Rieger-Fackeldey Andrey Kovtanyuk Renée Lampe |
| author_sort | Irina Sidorenko |
| collection | DOAJ |
| description | Intraventricular hemorrhage (IVH) is one of the most critical complications in the development of preterm infants. The likelihood of IVH is strongly associated with disturbances in cerebral blood flow (CBF) and with microvascular fragility in the germinal matrix (GM). The CBF value and its reactivity to changes in arterial carbon dioxide pressure (pCO2) and mean arterial blood pressure (MABP) are relevant indicators in the clinical assessment of preterm infants. The objective of the present study is mathematical modeling of the influence of pCO2 and MABP on CBF in immature brain, based on clinical data collected from 265 preterm infants with 23–30 gestational weeks. The model was adapted to the peculiarities of immature brain by taking into account the morphological characteristics of the GM capillary network and vascular reactivity, according to gestational and postnatal age. An analysis of model based values of CBF and its reactivity to changes in MABP and pCO2 was performed separately for each gestational week and for the first two days of life both for preterm infants with and without IVH. The developed model for the estimation of CBF was validated against equivalent experimental measurements taken from the literature. A good agreement between the estimated values of CBF, as well as its reaction on changes in MABP and pCO2 and the equivalent values obtained in experimental studies was shown. |
| first_indexed | 2024-12-14T16:44:03Z |
| format | Article |
| id | doaj.art-41ab782a8c004063868c61fe1732215f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T16:44:03Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-41ab782a8c004063868c61fe1732215f2022-12-21T22:54:15ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-10-01910.3389/fneur.2018.00812410796Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal MatrixIrina Sidorenko0Varvara Turova1Nikolai Botkin2Laura Eckardt3Ana Alves-Pinto4Ursula Felderhoff-Müser5Esther Rieger-Fackeldey6Andrey Kovtanyuk7Renée Lampe8Mathematical Faculty, Technical University of Munich, Garching, GermanyOrthopedic Department, University Hospital Rechts der Isar, Technical University of Munich, Munich, GermanyMathematical Faculty, Technical University of Munich, Garching, GermanyPediatric Department I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Essen, GermanyOrthopedic Department, University Hospital Rechts der Isar, Technical University of Munich, Munich, GermanyPediatric Department I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Essen, GermanyPediatric Department, University Hospital Rechts der Isar, Technical University of Munich, Munich, GermanyOrthopedic Department, University Hospital Rechts der Isar, Technical University of Munich, Munich, GermanyOrthopedic Department, University Hospital Rechts der Isar, Technical University of Munich, Munich, GermanyIntraventricular hemorrhage (IVH) is one of the most critical complications in the development of preterm infants. The likelihood of IVH is strongly associated with disturbances in cerebral blood flow (CBF) and with microvascular fragility in the germinal matrix (GM). The CBF value and its reactivity to changes in arterial carbon dioxide pressure (pCO2) and mean arterial blood pressure (MABP) are relevant indicators in the clinical assessment of preterm infants. The objective of the present study is mathematical modeling of the influence of pCO2 and MABP on CBF in immature brain, based on clinical data collected from 265 preterm infants with 23–30 gestational weeks. The model was adapted to the peculiarities of immature brain by taking into account the morphological characteristics of the GM capillary network and vascular reactivity, according to gestational and postnatal age. An analysis of model based values of CBF and its reactivity to changes in MABP and pCO2 was performed separately for each gestational week and for the first two days of life both for preterm infants with and without IVH. The developed model for the estimation of CBF was validated against equivalent experimental measurements taken from the literature. A good agreement between the estimated values of CBF, as well as its reaction on changes in MABP and pCO2 and the equivalent values obtained in experimental studies was shown.https://www.frontiersin.org/article/10.3389/fneur.2018.00812/fullintraventricular hemorrhagegerminal matrixcerebral autoregulationgestational agecapillary wall tension |
| spellingShingle | Irina Sidorenko Varvara Turova Nikolai Botkin Laura Eckardt Ana Alves-Pinto Ursula Felderhoff-Müser Esther Rieger-Fackeldey Andrey Kovtanyuk Renée Lampe Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix Frontiers in Neurology intraventricular hemorrhage germinal matrix cerebral autoregulation gestational age capillary wall tension |
| title | Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix |
| title_full | Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix |
| title_fullStr | Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix |
| title_full_unstemmed | Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix |
| title_short | Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix |
| title_sort | modeling cerebral blood flow dependence on carbon dioxide and mean arterial blood pressure in the immature brain with accounting for the germinal matrix |
| topic | intraventricular hemorrhage germinal matrix cerebral autoregulation gestational age capillary wall tension |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00812/full |
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