Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats
Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems. In this study, conducted in li...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2021-11-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/37541 |
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| author | Nataliya Badiuk Dariya Popovych Myroslava Hrytsak Sofiya Ruzhylo Nataliya Zakalyak Galyna Kovalchuk Oksana Mel’nyk Xawery Zukow |
| author_facet | Nataliya Badiuk Dariya Popovych Myroslava Hrytsak Sofiya Ruzhylo Nataliya Zakalyak Galyna Kovalchuk Oksana Mel’nyk Xawery Zukow |
| author_sort | Nataliya Badiuk |
| collection | DOAJ |
| description |
Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems. In this study, conducted in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum, data on the immunomodulatory effects of these waters on the same rats. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The object of the study were the immune parameters of the thymus, spleen and blood. Results. The method of discriminant analysis revealed 12 parameters, according to which the animals loaded with mineral waters differed significantly from both control and intact animals. Classification accuracy is 86%. However, the difference between the immunotropic effects of mineral waters of different mineralization concerns only 9 parameters. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both similar and specific immunomodulating effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.
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| first_indexed | 2024-12-10T10:29:55Z |
| format | Article |
| id | doaj.art-41ac0421c97f47ef9e4e8bd06de7b662 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-10T10:29:55Z |
| publishDate | 2021-11-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-41ac0421c97f47ef9e4e8bd06de7b6622022-12-22T01:52:36ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062021-11-01111110.12775/JEHS.2021.11.11.031Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female ratsNataliya Badiuk0Dariya Popovych1Myroslava Hrytsak2Sofiya Ruzhylo3Nataliya Zakalyak4Galyna Kovalchuk5Oksana Mel’nyk6Xawery Zukow7SE Ukrainian Research Institute of Medicine of Transport, OdesaIY Horbachevs’kyi National Medical University, Ternopil’SE Ukrainian Research Institute of Medicine of Transport, Odesa; Scientific group of Balneology of Hotel&Spa Complex "Karpaty"Ivan Franko Pedagogical University, DrohobychIvan Franko Pedagogical University, DrohobychIvan Franko Pedagogical University, DrohobychDanylo Halyts’kyǐ National Medical University, L’vivMedical University of Bialystok, Bialystok Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems. In this study, conducted in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum, data on the immunomodulatory effects of these waters on the same rats. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The object of the study were the immune parameters of the thymus, spleen and blood. Results. The method of discriminant analysis revealed 12 parameters, according to which the animals loaded with mineral waters differed significantly from both control and intact animals. Classification accuracy is 86%. However, the difference between the immunotropic effects of mineral waters of different mineralization concerns only 9 parameters. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both similar and specific immunomodulating effects on healthy old female rats with weekly use. This provides a basis for preclinical studies. https://apcz.umk.pl/JEHS/article/view/37541sulfate-chloride sodium-magnesium mineral watersimmunityfemale rats |
| spellingShingle | Nataliya Badiuk Dariya Popovych Myroslava Hrytsak Sofiya Ruzhylo Nataliya Zakalyak Galyna Kovalchuk Oksana Mel’nyk Xawery Zukow Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats Journal of Education, Health and Sport sulfate-chloride sodium-magnesium mineral waters immunity female rats |
| title | Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_full | Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_fullStr | Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_full_unstemmed | Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_short | Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats |
| title_sort | similar and specific immunotropic effects of sulfate chloride sodium magnesium mineral waters myroslava and khrystyna of truskavets spa in healthy female rats |
| topic | sulfate-chloride sodium-magnesium mineral waters immunity female rats |
| url | https://apcz.umk.pl/JEHS/article/view/37541 |
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