Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction
Limited data exist on the temporal trend of major bleeding and its prediction by the Academic Research Consortium-High Bleeding Risk (ARC-HBR) criteria in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). We investigated 10-year trends of major bleeding...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/4/988 |
| _version_ | 1797479104052723712 |
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| author | Sungwook Byun Eun Ho Choo Gyu-Chul Oh Sungmin Lim Ik Jun Choi Kwan Yong Lee Su Nam Lee Byung-Hee Hwang Chan Joon Kim Mahn-Won Park Chul Soo Park Hee-Yeol Kim Ki-Dong Yoo Doo Soo Jeon Ho Joong Youn Wook Sung Chung Min Chul Kim Myung Ho Jeong Hyeon-Woo Yim Youngkeun Ahn Kiyuk Chang |
| author_facet | Sungwook Byun Eun Ho Choo Gyu-Chul Oh Sungmin Lim Ik Jun Choi Kwan Yong Lee Su Nam Lee Byung-Hee Hwang Chan Joon Kim Mahn-Won Park Chul Soo Park Hee-Yeol Kim Ki-Dong Yoo Doo Soo Jeon Ho Joong Youn Wook Sung Chung Min Chul Kim Myung Ho Jeong Hyeon-Woo Yim Youngkeun Ahn Kiyuk Chang |
| author_sort | Sungwook Byun |
| collection | DOAJ |
| description | Limited data exist on the temporal trend of major bleeding and its prediction by the Academic Research Consortium-High Bleeding Risk (ARC-HBR) criteria in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). We investigated 10-year trends of major bleeding and predictive ability of the ARC-HBR criteria in AMI patients. In a multicenter registry of 10,291 AMI patients undergoing PCI between 2004 and 2014 the incidence of Bleeding Academic Research Consortium (BARC) 3 and 5 bleeding was assessed, and, outcomes in ARC-defined HBR patients with AMI were compared with those in non-HBR. The primary outcome was BARC 3 and 5 bleeding at 1 year. Secondary outcomes included all-cause mortality and composite of cardiovascular death, myocardial infarction, or ischemic stroke. The annual incidence of BARC 3 and 5 bleeding in the AMI population has increased over the years (1.8% to 5.8%; <i>p</i> < 0.001). At 1 year, ARC-defined HBR (<i>n</i> = 3371, 32.8%) had significantly higher incidence of BARC 3 and 5 bleeding (9.8% vs. 2.9%; <i>p</i> < 0.001), all-cause mortality (22.8% vs. 4.3%; <i>p</i> < 0.001) and composite of ischemic events (22.6% vs. 5.8%; <i>p</i> < 0.001) compared to non-HBR. During the past decade, the incidence of major bleeding in the AMI population has increased. The ARC-HBR criteria provided reliable predictions for major bleeding, mortality, and ischemic events in AMI patients. |
| first_indexed | 2024-03-09T21:41:31Z |
| format | Article |
| id | doaj.art-41ac169ce026423db11bfe974edd034c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:41:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-41ac169ce026423db11bfe974edd034c2023-11-23T20:29:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-0111498810.3390/jcm11040988Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial InfarctionSungwook Byun0Eun Ho Choo1Gyu-Chul Oh2Sungmin Lim3Ik Jun Choi4Kwan Yong Lee5Su Nam Lee6Byung-Hee Hwang7Chan Joon Kim8Mahn-Won Park9Chul Soo Park10Hee-Yeol Kim11Ki-Dong Yoo12Doo Soo Jeon13Ho Joong Youn14Wook Sung Chung15Min Chul Kim16Myung Ho Jeong17Hyeon-Woo Yim18Youngkeun Ahn19Kiyuk Chang20Division of Cardiology, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju 61469, KoreaDivision of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju 61469, KoreaClinical Research Coordinating Center, Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDivision of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju 61469, KoreaDivision of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaLimited data exist on the temporal trend of major bleeding and its prediction by the Academic Research Consortium-High Bleeding Risk (ARC-HBR) criteria in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). We investigated 10-year trends of major bleeding and predictive ability of the ARC-HBR criteria in AMI patients. In a multicenter registry of 10,291 AMI patients undergoing PCI between 2004 and 2014 the incidence of Bleeding Academic Research Consortium (BARC) 3 and 5 bleeding was assessed, and, outcomes in ARC-defined HBR patients with AMI were compared with those in non-HBR. The primary outcome was BARC 3 and 5 bleeding at 1 year. Secondary outcomes included all-cause mortality and composite of cardiovascular death, myocardial infarction, or ischemic stroke. The annual incidence of BARC 3 and 5 bleeding in the AMI population has increased over the years (1.8% to 5.8%; <i>p</i> < 0.001). At 1 year, ARC-defined HBR (<i>n</i> = 3371, 32.8%) had significantly higher incidence of BARC 3 and 5 bleeding (9.8% vs. 2.9%; <i>p</i> < 0.001), all-cause mortality (22.8% vs. 4.3%; <i>p</i> < 0.001) and composite of ischemic events (22.6% vs. 5.8%; <i>p</i> < 0.001) compared to non-HBR. During the past decade, the incidence of major bleeding in the AMI population has increased. The ARC-HBR criteria provided reliable predictions for major bleeding, mortality, and ischemic events in AMI patients.https://www.mdpi.com/2077-0383/11/4/988acute myocardial infarctionpercutaneous coronary interventionbleeding risk |
| spellingShingle | Sungwook Byun Eun Ho Choo Gyu-Chul Oh Sungmin Lim Ik Jun Choi Kwan Yong Lee Su Nam Lee Byung-Hee Hwang Chan Joon Kim Mahn-Won Park Chul Soo Park Hee-Yeol Kim Ki-Dong Yoo Doo Soo Jeon Ho Joong Youn Wook Sung Chung Min Chul Kim Myung Ho Jeong Hyeon-Woo Yim Youngkeun Ahn Kiyuk Chang Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction Journal of Clinical Medicine acute myocardial infarction percutaneous coronary intervention bleeding risk |
| title | Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction |
| title_full | Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction |
| title_fullStr | Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction |
| title_full_unstemmed | Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction |
| title_short | Temporal Trends of Major Bleeding and Its Prediction by the Academic Research Consortium-High Bleeding Risk Criteria in Acute Myocardial Infarction |
| title_sort | temporal trends of major bleeding and its prediction by the academic research consortium high bleeding risk criteria in acute myocardial infarction |
| topic | acute myocardial infarction percutaneous coronary intervention bleeding risk |
| url | https://www.mdpi.com/2077-0383/11/4/988 |
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