Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
Summary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significan...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422300826X |
| _version_ | 1797830021867372544 |
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| author | Lan Zhang Hongliang Zeng Ling Jiang Chuhan Fu Yushan Zhang Yibo Hu Xiaolin Zhang Lu Zhu Fan Zhang Jinhua Huang Jing Chen Qinghai Zeng |
| author_facet | Lan Zhang Hongliang Zeng Ling Jiang Chuhan Fu Yushan Zhang Yibo Hu Xiaolin Zhang Lu Zhu Fan Zhang Jinhua Huang Jing Chen Qinghai Zeng |
| author_sort | Lan Zhang |
| collection | DOAJ |
| description | Summary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significant pigmentation when exposed to 41°C. Furthermore, heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes. High-throughput RNA sequencing showed that heat stress activates the Hedgehog (Hh) signaling pathway in keratinocytes. The agonists of Hh signaling promote the paracrine effect of keratinocytes on melanogenesis. In addition, transient receptor potential vanilloid (TRPV) 3 agonists activate the Hh signaling in keratinocytes and augment its paracrine effect on melanogenesis. The heat-induced activation of Hh signaling is dependent on TRPV3-mediated Ca2+ influx. Heat exposure promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway. Our findings provide insights into the mechanisms of heat-induced skin pigmentation. |
| first_indexed | 2024-04-09T13:29:26Z |
| format | Article |
| id | doaj.art-41ada1923b444ccb990a718ffbfc26d9 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T13:29:26Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-41ada1923b444ccb990a718ffbfc26d92023-05-10T04:19:48ZengElsevieriScience2589-00422023-05-01265106749Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathwayLan Zhang0Hongliang Zeng1Ling Jiang2Chuhan Fu3Yushan Zhang4Yibo Hu5Xiaolin Zhang6Lu Zhu7Fan Zhang8Jinhua Huang9Jing Chen10Qinghai Zeng11Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaCenter of Medical Laboratory Animal, Hunan Academy of Chinese Medicine, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China; Corresponding authorSummary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significant pigmentation when exposed to 41°C. Furthermore, heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes. High-throughput RNA sequencing showed that heat stress activates the Hedgehog (Hh) signaling pathway in keratinocytes. The agonists of Hh signaling promote the paracrine effect of keratinocytes on melanogenesis. In addition, transient receptor potential vanilloid (TRPV) 3 agonists activate the Hh signaling in keratinocytes and augment its paracrine effect on melanogenesis. The heat-induced activation of Hh signaling is dependent on TRPV3-mediated Ca2+ influx. Heat exposure promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway. Our findings provide insights into the mechanisms of heat-induced skin pigmentation.http://www.sciencedirect.com/science/article/pii/S258900422300826XBiological sciencesMolecular biologyCell biology |
| spellingShingle | Lan Zhang Hongliang Zeng Ling Jiang Chuhan Fu Yushan Zhang Yibo Hu Xiaolin Zhang Lu Zhu Fan Zhang Jinhua Huang Jing Chen Qinghai Zeng Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway iScience Biological sciences Molecular biology Cell biology |
| title | Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway |
| title_full | Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway |
| title_fullStr | Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway |
| title_full_unstemmed | Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway |
| title_short | Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway |
| title_sort | heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the trpv3 ca2 hh signaling pathway |
| topic | Biological sciences Molecular biology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S258900422300826X |
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