Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats
Decision-making behavior is often characterized by substantial variability, but its source remains unclear. We developed a visual accumulation of evidence task designed to quantify sources of noise and to be performed during voluntary head restraint, enabling cellular resolution imaging in future st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/11308 |
| _version_ | 1818019098009796608 |
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| author | Benjamin B Scott Christine M Constantinople Jeffrey C Erlich David W Tank Carlos D Brody |
| author_facet | Benjamin B Scott Christine M Constantinople Jeffrey C Erlich David W Tank Carlos D Brody |
| author_sort | Benjamin B Scott |
| collection | DOAJ |
| description | Decision-making behavior is often characterized by substantial variability, but its source remains unclear. We developed a visual accumulation of evidence task designed to quantify sources of noise and to be performed during voluntary head restraint, enabling cellular resolution imaging in future studies. Rats accumulated discrete numbers of flashes presented to the left and right visual hemifields and indicated the side that had the greater number of flashes. Using a signal-detection theory-based model, we found that the standard deviation in their internal estimate of flash number scaled linearly with the number of flashes. This indicates a major source of noise that, surprisingly, is not consistent with the widely used 'drift-diffusion modeling' (DDM) approach but is instead closely related to proposed models of numerical cognition and counting. We speculate that this form of noise could be important in accumulation of evidence tasks generally. |
| first_indexed | 2024-04-14T07:46:58Z |
| format | Article |
| id | doaj.art-41b0cd1523124c58a8e3fd5e8d000b68 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:46:58Z |
| publishDate | 2015-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-41b0cd1523124c58a8e3fd5e8d000b682022-12-22T02:05:18ZengeLife Sciences Publications LtdeLife2050-084X2015-12-01410.7554/eLife.11308Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained ratsBenjamin B Scott0Christine M Constantinople1Jeffrey C Erlich2https://orcid.org/0000-0001-9073-7986David W Tank3Carlos D Brody4Princeton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United StatesNYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, ChinaPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Bezos Center for Neural Circuit Dynamics, Princeton University, Princeton, United StatesPrinceton Neuroscience Institute, Princeton University, Princeton, United States; Department of Molecular Biology, Princeton University, Princeton, United States; Howard Hughes Medical Institute, Princeton University, Princeton, United StatesDecision-making behavior is often characterized by substantial variability, but its source remains unclear. We developed a visual accumulation of evidence task designed to quantify sources of noise and to be performed during voluntary head restraint, enabling cellular resolution imaging in future studies. Rats accumulated discrete numbers of flashes presented to the left and right visual hemifields and indicated the side that had the greater number of flashes. Using a signal-detection theory-based model, we found that the standard deviation in their internal estimate of flash number scaled linearly with the number of flashes. This indicates a major source of noise that, surprisingly, is not consistent with the widely used 'drift-diffusion modeling' (DDM) approach but is instead closely related to proposed models of numerical cognition and counting. We speculate that this form of noise could be important in accumulation of evidence tasks generally.https://elifesciences.org/articles/11308decision-makingaccumulation of evidencehead restraintdrift diffusion modelsignal detection theory |
| spellingShingle | Benjamin B Scott Christine M Constantinople Jeffrey C Erlich David W Tank Carlos D Brody Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats eLife decision-making accumulation of evidence head restraint drift diffusion model signal detection theory |
| title | Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats |
| title_full | Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats |
| title_fullStr | Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats |
| title_full_unstemmed | Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats |
| title_short | Sources of noise during accumulation of evidence in unrestrained and voluntarily head-restrained rats |
| title_sort | sources of noise during accumulation of evidence in unrestrained and voluntarily head restrained rats |
| topic | decision-making accumulation of evidence head restraint drift diffusion model signal detection theory |
| url | https://elifesciences.org/articles/11308 |
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