Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
Inhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinase...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15067-5 |
| _version_ | 1818342451338805248 |
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| author | Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh |
| author_facet | Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh |
| author_sort | Mohamed Mahameed |
| collection | DOAJ |
| description | Inhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinases, suggesting a selective ER retention. |
| first_indexed | 2024-12-13T16:14:54Z |
| format | Article |
| id | doaj.art-41b3dd4a0c9748dc8d4f1d07443c6ee2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:14:54Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-41b3dd4a0c9748dc8d4f1d07443c6ee22022-12-21T23:38:51ZengNature PortfolioNature Communications2041-17232020-03-0111111410.1038/s41467-020-15067-5Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapyMohamed Mahameed0Shatha Boukeileh1Akram Obiedat2Odai Darawshi3Priya Dipta4Amit Rimon5Gordon McLennan6Rosi Fassler7Dana Reichmann8Rotem Karni9Christian Preisinger10Thomas Wilhelm11Michael Huber12Boaz Tirosh13Institute for Drug Research, The Hebrew University of JerusalemInstitute for Drug Research, The Hebrew University of JerusalemInstitute for Drug Research, The Hebrew University of JerusalemInstitute for Drug Research, The Hebrew University of JerusalemInstitute for Drug Research, The Hebrew University of JerusalemInstitute for Drug Research, The Hebrew University of JerusalemLerner Research Institute, Cleveland Clinic FoundationThe Alexander Silberman Institute of Life Sciences, The Hebrew University of JerusalemThe Alexander Silberman Institute of Life Sciences, The Hebrew University of JerusalemDepartment of Biochemistry, Faculty of Medicine, IMRIC, The Hebrew University of JerusalemProteomics Facility, IZKF Aachen, RWTH Aachen UniversityInstitute of Biochemistry and Molecular Immunology, Medical School, RWTH Aachen UniversityInstitute of Biochemistry and Molecular Immunology, Medical School, RWTH Aachen UniversityInstitute for Drug Research, The Hebrew University of JerusalemInhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinases, suggesting a selective ER retention.https://doi.org/10.1038/s41467-020-15067-5 |
| spellingShingle | Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy Nature Communications |
| title | Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| title_full | Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| title_fullStr | Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| title_full_unstemmed | Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| title_short | Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| title_sort | pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy |
| url | https://doi.org/10.1038/s41467-020-15067-5 |
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