The Double-Leucine Motifs Affect Internalization, Stability, and Function of Organic Anion Transporting Polypeptide 1B1

The Double-Leucine Motifs Affect Internalization, Stability, and Function of Organic Anion Transporting Polypeptide 1B1

Organic anion transporting polypeptide 1B1 (OATP1B1) is specifically expressed at the basolateral membrane of human hepatocytes and plays important roles in the uptake of various endogenous and exogenous compounds including many drugs. The proper functioning of OATP1B1, hence, is essential for the b...

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Bibliographic Details
Main Authors: Xuyang Wang, Jieru Chen, Jiujiu Huang, Mei Hong
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
OATP1B1
double-leucine motifs
intracellular loops
transmembrane helices
transport function
Online Access:https://www.mdpi.com/1999-4923/15/9/2279

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