Probing Anti-Leukemic Metabolites from Marine-Derived <i>Streptomyces</i> sp. LY1209

Probing Anti-Leukemic Metabolites from Marine-Derived <i>Streptomyces</i> sp. LY1209

The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of <i>Streptomyces</i> sp. LY1209 exhibited the most potent anti-proliferative effect against Molt 4 le...

Full description

Bibliographic Details
Main Authors:	You-Ying Chen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Bo-Rong Peng, Yu-Cheng Chen, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Pei-Tzu Yen, Lung-Shuo Wang, Kuei-Hung Lai
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Series:	Metabolites
Subjects:	<i>Streptomyces</i> sp. LY1209 chromatographic bioassay profile staurosporine diketopiperazines
Online Access:	https://www.mdpi.com/2218-1989/12/4/320

Similar Items

Antiamoebic Activities of Indolocarbazole Metabolites Isolated from <i>Streptomyces sanyensis</i> Cultures
by: Luis Cartuche, et al.
Published: (2019-10-01)

Antimicrobial Chlorinated 3-Phenylpropanoic Acid Derivatives from the Red Sea Marine Actinomycete <i>Streptomyces</i> <i>coelicolor</i> LY001
by: Lamiaa A. Shaala, et al.
Published: (2020-08-01)

The Inhibition Effect and Mechanism of Staurosporine Isolated from <i>Streptomyces</i> sp. SNC087 Strain on Nasal Polyp
by: Grace Choi, et al.
Published: (2024-01-01)

Inhibitory Effects of Diketopiperazines from Marine-Derived <i>Streptomyces puniceus</i> on the Isocitrate Lyase of <i>Candida albicans</i>
by: Heegyu Kim, et al.
Published: (2019-06-01)

A randomized, double-blind, parallel control study to evaluate the biosimilarity of QL1209 with Perjeta® in healthy male subjects
by: Yuanyuan Sun, et al.
Published: (2022-08-01)

Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
by: Heidrun Moll, et al.
Published: (2010-02-01)

Actinomycins from Soil-Inhabiting <i>Streptomyces</i> as Sources of Antibacterial Pigments for Silk Dyeing
by: Tananya Nuanjohn, et al.
Published: (2023-08-01)

New Antifungal Metabolites from the Mariana Trench Sediment-Associated Actinomycete <i>Streptomyces</i> sp. SY1965
by: Wenwen Yi, et al.
Published: (2020-07-01)

Evaluation of Indolocarbazoles from <i>Streptomyces sanyensis</i> as a Novel Source of Therapeutic Agents against the Brain-Eating Amoeba <i>Naegleria fowleri</i>
by: Aitor Rizo-Liendo, et al.
Published: (2020-05-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2015-11-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2010-11-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2010-11-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2015-11-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2015-11-01)

Cooking with Fresh Herbs
by: Emily Minton, et al.
Published: (2010-11-01)

Bioactive Diketopiperazines and Nucleoside Derivatives from a Sponge-Derived <i>Streptomyces</i> Species
by: Lamiaa A. Shaala, et al.
Published: (2019-10-01)

Diketopiperazine Derivatives from the Marine-Derived Actinomycete Streptomyces sp. FXJ7.328
by: Weiming Zhu, et al.
Published: (2013-03-01)

Enhanced Oxytetracycline Production by <i>Streptomyces rimosus</i> in Submerged Co-Cultures with <i>Streptomyces noursei</i>
by: Tomasz Boruta, et al.
Published: (2021-10-01)

α-Glucosidase Inhibitors from Two Mangrove-Derived Actinomycetes
by: Xuejun Lu, et al.
Published: (2023-04-01)

<i>Streptomyces</i> Diversity Maps Reveal Distinct High-Specificity Biogeographical and Environmental Patterns Compared to the Overall Bacterial Diversity
by: Nuttapon Pombubpa, et al.
Published: (2023-12-01)

Biosynthesis of (±)-Differolide, an Antioxidant Isolate from <i>Streptomyces qaidamensis</i> S10<sup>T</sup>
by: Yujie Wu, et al.
Published: (2022-04-01)

Recent Advances in the Heterologous Biosynthesis of Natural Products from <i>Streptomyces</i>
by: Van Thuy Thi Pham, et al.
Published: (2021-02-01)

Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity
by: Cao Van Anh, et al.
Published: (2023-06-01)

Antikinetoplastid Activity of Indolocarbazoles from <i>Streptomyces sanyensis</i>
by: Luis Cartuche, et al.
Published: (2020-04-01)

Challenges and Advances in Genome Editing Technologies in <i>Streptomyces</i>
by: Yawei Zhao, et al.
Published: (2020-05-01)

Biochemical Characterization of an Arabinoside Monophosphate Specific 5′-Nucleotidase-like Enzyme from <i>Streptomyces antibioticus</i>
by: Yuxue Liu, et al.
Published: (2024-10-01)

New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
by: Constanze Paulus, et al.
Published: (2021-11-01)

Isolation and Identification of Pentalenolactone Analogs from <i>Streptomyces</i> sp. NRRL S-4
by: Huanhuan Li, et al.
Published: (2021-12-01)

Staurosporine as a Potential Treatment for <i>Acanthamoeba</i> Keratitis Using Mouse Cornea as an Ex Vivo Model
by: Rubén L. Rodríguez-Expósito, et al.
Published: (2024-09-01)

Recent Progress of Reclassification of the Genus <i>Streptomyces</i>
by: Hisayuki Komaki
Published: (2023-03-01)

New Strains of <i>Streptomyces</i> as Perspective Antagonists of Microbial Phytopathogens
by: Valentina N. Polivtseva, et al.
Published: (2023-05-01)

Biosynthetic Potential of <i>Streptomyces</i> Rationalizes Genome-Based Bioprospecting
by: Balasubramanian Cibichakravarthy, et al.
Published: (2021-07-01)

Antibiotic Potential of Marine Actinomycetes of the Genera <i>Streptomyces</i> and <i>Nocardiopsis</i>
by: O. N. Sineva, et al.
Published: (2023-07-01)

The Probiotic Potential and Metabolite Characterization of Bioprotective <i>Bacillus</i> and <i>Streptomyces</i> for Applications in Animal Production
by: Alberto Gonçalves Evangelista, et al.
Published: (2024-01-01)

Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from <i>Streptomyces</i> sp. MS751
by: Jiaming Yu, et al.
Published: (2024-06-01)

Determinants of private saving with special reference to the role of social security : cross country tests
Published: (2003)

Absolute Configurations and Chitinase Inhibitions of Quinazoline-Containing Diketopiperazines from the Marine-Derived Fungus <i>Penicillium polonicum</i>
by: Xing-Chen Guo, et al.
Published: (2020-09-01)

Optimization of Milbemycin Component Ratio by Coordinating Acyl-Coenzyme A Supply Pathways in <i>Streptomyces bingchenggensis</i>
by: Xue Yang, et al.
Published: (2023-06-01)

The Anti-Proliferative Activity of Secondary Metabolite from the Marine <i>Streptomyces</i> sp. against Prostate Cancer Cells
by: Hung-Yu Lin, et al.
Published: (2021-12-01)

An Overview of Lsr2 Repressor Effect in <i>Streptomyces</i> spp. Secondary Metabolism
by: Lorena Cuervo, et al.
Published: (2024-11-01)