Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke

Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke

Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury. Previous data in experimental models of stroke show that ischemia leads to the accumulation of succinate, and, upon reperfusion,...

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Bibliographic Details
Main Authors: Amin Mottahedin, Hiran A. Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J. Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M. Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P. Murphy, Thomas Krieg
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000010

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http://www.sciencedirect.com/science/article/pii/S2213231723000010

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