Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation
Targeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2022-01-01
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| Series: | Cyborg and Bionic Systems |
| Online Access: | http://dx.doi.org/10.34133/2022/9759265 |
| _version_ | 1811258464300695552 |
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| author | Siyang Zhong Zijun Zhang Huan Su Chenyang Li Yifeng Lin Wei Lu Zhendong Jiang Lin Yang |
| author_facet | Siyang Zhong Zijun Zhang Huan Su Chenyang Li Yifeng Lin Wei Lu Zhendong Jiang Lin Yang |
| author_sort | Siyang Zhong |
| collection | DOAJ |
| description | Targeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment of the patient’s denervated muscle or proximal nerve stump as well as nerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery. In this experiment, we successfully established a TMR rat model and divided Sprague-Dawley (SD) adult male rats into TMR group, TMR + FES group, and TMR + NGF group according to TMR and whether they received FES treatment or NGF injection after surgery, and the recovery effect of rat neuromuscular function was assessed by analyzing EMG signals. Through the experiments, we confirmed that growth factor supplementation and low-frequency electrical stimulation can effectively promote the regeneration of the transplanted nerve as well as significantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve. |
| first_indexed | 2024-04-12T18:14:48Z |
| format | Article |
| id | doaj.art-41b834cb89514d55be263f77cc309efc |
| institution | Directory Open Access Journal |
| issn | 2692-7632 |
| language | English |
| last_indexed | 2024-04-12T18:14:48Z |
| publishDate | 2022-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Cyborg and Bionic Systems |
| spelling | doaj.art-41b834cb89514d55be263f77cc309efc2022-12-22T03:21:41ZengAmerican Association for the Advancement of Science (AAAS)Cyborg and Bionic Systems2692-76322022-01-01202210.34133/2022/9759265Efficacy of Biological and Physical Enhancement on Targeted Muscle ReinnervationSiyang Zhong0Zijun Zhang1Huan Su2Chenyang Li3Yifeng Lin4Wei Lu5Zhendong Jiang6Lin Yang7Department of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaSchool of Resources, Environmental and Chemical Engineering, Nanchang University, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaDepartment of Basic Education, Zhuhai Campus of Zunyi Medical University, Zhuhai, China; CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaTargeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment of the patient’s denervated muscle or proximal nerve stump as well as nerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery. In this experiment, we successfully established a TMR rat model and divided Sprague-Dawley (SD) adult male rats into TMR group, TMR + FES group, and TMR + NGF group according to TMR and whether they received FES treatment or NGF injection after surgery, and the recovery effect of rat neuromuscular function was assessed by analyzing EMG signals. Through the experiments, we confirmed that growth factor supplementation and low-frequency electrical stimulation can effectively promote the regeneration of the transplanted nerve as well as significantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve.http://dx.doi.org/10.34133/2022/9759265 |
| spellingShingle | Siyang Zhong Zijun Zhang Huan Su Chenyang Li Yifeng Lin Wei Lu Zhendong Jiang Lin Yang Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation Cyborg and Bionic Systems |
| title | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation |
| title_full | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation |
| title_fullStr | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation |
| title_full_unstemmed | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation |
| title_short | Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation |
| title_sort | efficacy of biological and physical enhancement on targeted muscle reinnervation |
| url | http://dx.doi.org/10.34133/2022/9759265 |
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