Current pain management strategies for patients with erythromelalgia: a critical review
See Wan Tham,1,2 Marian Giles1,2 1Seattle Children’s Research Institute, Seattle, WA, USA; 2Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA Abstract: Erythromelalgia (EM) is a rare disorder characterized by erythematous, warm, p...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-08-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/current-pain-management-strategies-for-patients-with-erythromelalgia-a-peer-reviewed-article-JPR |
| _version_ | 1818672079387492352 |
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| author | Tham SW Giles M |
| author_facet | Tham SW Giles M |
| author_sort | Tham SW |
| collection | DOAJ |
| description | See Wan Tham,1,2 Marian Giles1,2 1Seattle Children’s Research Institute, Seattle, WA, USA; 2Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA Abstract: Erythromelalgia (EM) is a rare disorder characterized by erythematous, warm, painful extremities, which is often precipitated by cold conditions. The pathophysiology of EM is incompletely understood. Recent investigations have identified sodium channelopathy as a genetic cause for this pain condition, classified as primary inherited EM. Other subtypes are idiopathic EM and secondary EM. The management of pain in EM is challenging as no single therapy has been found to be effective. There is varying response to pharmacotherapy and significant variability within this clinical population, resulting in a stepwise trial and error approach. Consequently, EM is often associated with poorer health-related quality of life with higher morbidity. There is currently no consensus or guidelines on management of pain in EM. This is a review of the literature on management of pain using pharmacologic, procedural intervention and nonpharmacologic treatment in children and adults with EM. Keywords: erythromelalgia, pain, voltage gated sodium channel, therapy |
| first_indexed | 2024-12-17T07:34:12Z |
| format | Article |
| id | doaj.art-41b940f88d844a4d9a0e3f7ef51e2bf8 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-17T07:34:12Z |
| publishDate | 2018-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-41b940f88d844a4d9a0e3f7ef51e2bf82022-12-21T21:58:23ZengDove Medical PressJournal of Pain Research1178-70902018-08-01Volume 111689169840207Current pain management strategies for patients with erythromelalgia: a critical reviewTham SWGiles MSee Wan Tham,1,2 Marian Giles1,2 1Seattle Children’s Research Institute, Seattle, WA, USA; 2Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA Abstract: Erythromelalgia (EM) is a rare disorder characterized by erythematous, warm, painful extremities, which is often precipitated by cold conditions. The pathophysiology of EM is incompletely understood. Recent investigations have identified sodium channelopathy as a genetic cause for this pain condition, classified as primary inherited EM. Other subtypes are idiopathic EM and secondary EM. The management of pain in EM is challenging as no single therapy has been found to be effective. There is varying response to pharmacotherapy and significant variability within this clinical population, resulting in a stepwise trial and error approach. Consequently, EM is often associated with poorer health-related quality of life with higher morbidity. There is currently no consensus or guidelines on management of pain in EM. This is a review of the literature on management of pain using pharmacologic, procedural intervention and nonpharmacologic treatment in children and adults with EM. Keywords: erythromelalgia, pain, voltage gated sodium channel, therapyhttps://www.dovepress.com/current-pain-management-strategies-for-patients-with-erythromelalgia-a-peer-reviewed-article-JPRErythromelalgia Pain Pharmacotherapy |
| spellingShingle | Tham SW Giles M Current pain management strategies for patients with erythromelalgia: a critical review Journal of Pain Research Erythromelalgia Pain Pharmacotherapy |
| title | Current pain management strategies for patients with erythromelalgia: a critical review |
| title_full | Current pain management strategies for patients with erythromelalgia: a critical review |
| title_fullStr | Current pain management strategies for patients with erythromelalgia: a critical review |
| title_full_unstemmed | Current pain management strategies for patients with erythromelalgia: a critical review |
| title_short | Current pain management strategies for patients with erythromelalgia: a critical review |
| title_sort | current pain management strategies for patients with erythromelalgia a critical review |
| topic | Erythromelalgia Pain Pharmacotherapy |
| url | https://www.dovepress.com/current-pain-management-strategies-for-patients-with-erythromelalgia-a-peer-reviewed-article-JPR |
| work_keys_str_mv | AT thamsw currentpainmanagementstrategiesforpatientswitherythromelalgiaacriticalreview AT gilesm currentpainmanagementstrategiesforpatientswitherythromelalgiaacriticalreview |