Thermosensitive liposomal drug delivery systems: state of the art review
Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014-09-01
|
| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/thermosensitive-liposomal-drug-delivery-systems-state-of-the-art-revie-peer-reviewed-article-IJN |
| _version_ | 1818905863392329728 |
|---|---|
| author | Kneidl B Peller M Winter G Lindner LH Hossann M |
| author_facet | Kneidl B Peller M Winter G Lindner LH Hossann M |
| author_sort | Kneidl B |
| collection | DOAJ |
| description | Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, GermanyAbstract: Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.Keywords: thermosensitive liposomes, phosphatidyloligoglycerol, hyperthermia, high intensity focused ultrasound, drug delivery, drug targeting |
| first_indexed | 2024-12-19T21:30:05Z |
| format | Article |
| id | doaj.art-41b99938a1d74bf28d0ae0a000a01a2a |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-19T21:30:05Z |
| publishDate | 2014-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-41b99938a1d74bf28d0ae0a000a01a2a2022-12-21T20:04:56ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-09-012014Issue 14387439818360Thermosensitive liposomal drug delivery systems: state of the art reviewKneidl BPeller MWinter GLindner LHHossann MBarbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, GermanyAbstract: Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.Keywords: thermosensitive liposomes, phosphatidyloligoglycerol, hyperthermia, high intensity focused ultrasound, drug delivery, drug targetinghttp://www.dovepress.com/thermosensitive-liposomal-drug-delivery-systems-state-of-the-art-revie-peer-reviewed-article-IJN |
| spellingShingle | Kneidl B Peller M Winter G Lindner LH Hossann M Thermosensitive liposomal drug delivery systems: state of the art review International Journal of Nanomedicine |
| title | Thermosensitive liposomal drug delivery systems: state of the art review |
| title_full | Thermosensitive liposomal drug delivery systems: state of the art review |
| title_fullStr | Thermosensitive liposomal drug delivery systems: state of the art review |
| title_full_unstemmed | Thermosensitive liposomal drug delivery systems: state of the art review |
| title_short | Thermosensitive liposomal drug delivery systems: state of the art review |
| title_sort | thermosensitive liposomal drug delivery systems state of the art review |
| url | http://www.dovepress.com/thermosensitive-liposomal-drug-delivery-systems-state-of-the-art-revie-peer-reviewed-article-IJN |
| work_keys_str_mv | AT kneidlb thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview AT pellerm thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview AT winterg thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview AT lindnerlh thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview AT hossannm thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview |