The HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis

The HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis

Affibodies targeting intracellular proteins have a great potential to function as ideal therapeutic agents. However, little is known about how the affibodies enter target cells to interact with intracellular target proteins. We have previously developed the HPV16E7 affibody (Z<sub>HPV16E7</...

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Bibliographic Details
Main Authors: Qingyuan Zhang, Hua Zhu, Zhouying Cui, Yuxiao Li, Jiaying Zhuo, Jingwei Ye, Zhihui Zhang, Zheng Lian, Qianqian Du, Kong-Nan Zhao, Lifang Zhang, Pengfei Jiang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
affibody
intracellular target proteins
endocytosis
cell cycle arrest
inhibition of cell proliferation
Online Access:https://www.mdpi.com/2218-273X/12/8/1114

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