Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subje...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/11/1151 |
| _version_ | 1797509706100506624 |
|---|---|
| author | Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin |
| author_facet | Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin |
| author_sort | Sung-Hwa Ko |
| collection | DOAJ |
| description | One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subjects were divided into spasticity and control groups. We measured the ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values on the reticular formation (RF) of the CRP were on the DTI images. We carried out a retrospective analysis of 70 patients with ischemic stroke. The cFA values of CRP in the spasticity group were lower than those in the control group (<i>p</i> = 0.04). In the sub-ROI analysis of CRP, the iFA values of pontine RF were lower than the cFA values in both groups (<i>p</i> < 0.05). The cFA values of medullary RF in the spasticity group were lower than the iFA values within groups, and also lower than the cFA values in the control group (<i>p</i> < 0.05). This results showed the CRP injury and that imbalance of RST caused by CRP injury was associated with PSS. DTI analysis of CRP could provide imaging evidence for the pathophysiology of PSS. |
| first_indexed | 2024-03-10T05:21:33Z |
| format | Article |
| id | doaj.art-41bacb0f3bc147dda6e406cad4456b9b |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T05:21:33Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-41bacb0f3bc147dda6e406cad4456b9b2023-11-22T23:58:40ZengMDPI AGJournal of Personalized Medicine2075-44262021-11-011111115110.3390/jpm11111151Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging StudySung-Hwa Ko0Taehyung Kim1Ji Hong Min2Musu Kim3Hyun-Yoon Ko4Yong-Il Shin5Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaResearch Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaOne of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subjects were divided into spasticity and control groups. We measured the ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values on the reticular formation (RF) of the CRP were on the DTI images. We carried out a retrospective analysis of 70 patients with ischemic stroke. The cFA values of CRP in the spasticity group were lower than those in the control group (<i>p</i> = 0.04). In the sub-ROI analysis of CRP, the iFA values of pontine RF were lower than the cFA values in both groups (<i>p</i> < 0.05). The cFA values of medullary RF in the spasticity group were lower than the iFA values within groups, and also lower than the cFA values in the control group (<i>p</i> < 0.05). This results showed the CRP injury and that imbalance of RST caused by CRP injury was associated with PSS. DTI analysis of CRP could provide imaging evidence for the pathophysiology of PSS.https://www.mdpi.com/2075-4426/11/11/1151corticoreticular pathwaydiffusion tensor imagingreticulospinal tractspasticitystroke |
| spellingShingle | Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study Journal of Personalized Medicine corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke |
| title | Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study |
| title_full | Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study |
| title_fullStr | Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study |
| title_full_unstemmed | Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study |
| title_short | Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study |
| title_sort | corticoreticular pathway in post stroke spasticity a diffusion tensor imaging study |
| topic | corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke |
| url | https://www.mdpi.com/2075-4426/11/11/1151 |
| work_keys_str_mv | AT sunghwako corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT taehyungkim corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT jihongmin corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT musukim corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT hyunyoonko corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT yongilshin corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy |