Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway
Natural products are one of the essential sources of innovative drugs. Trigothysoid N, a natural daphnane diterpenoid obtained from Trigonostemon thyrsoideus, possessed the strong ability to inhibit the proliferation of A549 cells. Besides interrupting the cell cycle, the mechanism examination revea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223003921 |
| _version_ | 1797803982261846016 |
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| author | Ying Li Yuhui Liu Yeling Li Feng Liu Yinan Zhao Jing Xu Yuanqiang Guo |
| author_facet | Ying Li Yuhui Liu Yeling Li Feng Liu Yinan Zhao Jing Xu Yuanqiang Guo |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Natural products are one of the essential sources of innovative drugs. Trigothysoid N, a natural daphnane diterpenoid obtained from Trigonostemon thyrsoideus, possessed the strong ability to inhibit the proliferation of A549 cells. Besides interrupting the cell cycle, the mechanism examination revealed that trigothysoid N can inhibit tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. In addition to the possible mechanism, in vivo antitumor experiments were performed to explore the potential of trigothysoid N for treating non-small cell lung cancer (NSCLC). Collectively, these findings supported the great potential of trigothysoid N as a hopeful therapeutic agent against NSCLC. |
| first_indexed | 2024-03-13T05:29:15Z |
| format | Article |
| id | doaj.art-41bb5cb9be9e42999cf91a1bb77a421b |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-13T05:29:15Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-41bb5cb9be9e42999cf91a1bb77a421b2023-06-15T04:54:57ZengElsevierArabian Journal of Chemistry1878-53522023-08-01168104930Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathwayYing Li0Yuhui Liu1Yeling Li2Feng Liu3Yinan Zhao4Jing Xu5Yuanqiang Guo6State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China; Corresponding authors at: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China (Y. Guo).State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571158, People's Republic of China; Corresponding authors at: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People’s Republic of China (Y. Guo).Natural products are one of the essential sources of innovative drugs. Trigothysoid N, a natural daphnane diterpenoid obtained from Trigonostemon thyrsoideus, possessed the strong ability to inhibit the proliferation of A549 cells. Besides interrupting the cell cycle, the mechanism examination revealed that trigothysoid N can inhibit tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. In addition to the possible mechanism, in vivo antitumor experiments were performed to explore the potential of trigothysoid N for treating non-small cell lung cancer (NSCLC). Collectively, these findings supported the great potential of trigothysoid N as a hopeful therapeutic agent against NSCLC.http://www.sciencedirect.com/science/article/pii/S1878535223003921Natural diterpenoidAnti-tumor activityZebrafish xenograft modelMitochondriaSTAT3FAK |
| spellingShingle | Ying Li Yuhui Liu Yeling Li Feng Liu Yinan Zhao Jing Xu Yuanqiang Guo Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway Arabian Journal of Chemistry Natural diterpenoid Anti-tumor activity Zebrafish xenograft model Mitochondria STAT3 FAK |
| title | Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway |
| title_full | Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway |
| title_fullStr | Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway |
| title_full_unstemmed | Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway |
| title_short | Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway |
| title_sort | trigothysoid n inhibits tumor proliferation and migration by targeting mitochondria and the stat3 fak pathway |
| topic | Natural diterpenoid Anti-tumor activity Zebrafish xenograft model Mitochondria STAT3 FAK |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223003921 |
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