Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway

Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway

Natural products are one of the essential sources of innovative drugs. Trigothysoid N, a natural daphnane diterpenoid obtained from Trigonostemon thyrsoideus, possessed the strong ability to inhibit the proliferation of A549 cells. Besides interrupting the cell cycle, the mechanism examination revea...

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Bibliographic Details
Main Authors: Ying Li, Yuhui Liu, Yeling Li, Feng Liu, Yinan Zhao, Jing Xu, Yuanqiang Guo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Arabian Journal of Chemistry
Subjects:
Natural diterpenoid
Anti-tumor activity
Zebrafish xenograft model
Mitochondria
STAT3
FAK
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223003921

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