Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic
RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Clinical Immunology Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772613423000070 |
| _version_ | 1827917634185723904 |
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| author | Christopher Costin Gabrielle Morgan Amer Khojah Marisa Klein-Gitelman Lauren M. Pachman |
| author_facet | Christopher Costin Gabrielle Morgan Amer Khojah Marisa Klein-Gitelman Lauren M. Pachman |
| author_sort | Christopher Costin |
| collection | DOAJ |
| description | RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM. |
| first_indexed | 2024-03-13T03:31:11Z |
| format | Article |
| id | doaj.art-41bcdaad9ab5455e9d358d7b09c835e4 |
| institution | Directory Open Access Journal |
| issn | 2772-6134 |
| language | English |
| last_indexed | 2024-03-13T03:31:11Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Immunology Communications |
| spelling | doaj.art-41bcdaad9ab5455e9d358d7b09c835e42023-06-24T05:20:04ZengElsevierClinical Immunology Communications2772-61342023-12-0134245Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemicChristopher Costin0Gabrielle Morgan1Amer Khojah2Marisa Klein-Gitelman3Lauren M. Pachman4Division of Pediatric Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, 225 East Chicago Ave, Box 50, Chicago IL, USA; Corresponding author.Division of Pediatric Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, 225 East Chicago Ave, Box 50, Chicago IL, USAPediatric Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDivision of Pediatric Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, 225 East Chicago Ave, Box 50, Chicago IL, USADivision of Pediatric Rheumatology, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, 225 East Chicago Ave, Box 50, Chicago IL, USARNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM.http://www.sciencedirect.com/science/article/pii/S2772613423000070Juvenile dermatomyositisNK CellsCOVID-19 |
| spellingShingle | Christopher Costin Gabrielle Morgan Amer Khojah Marisa Klein-Gitelman Lauren M. Pachman Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic Clinical Immunology Communications Juvenile dermatomyositis NK Cells COVID-19 |
| title | Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic |
| title_full | Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic |
| title_fullStr | Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic |
| title_full_unstemmed | Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic |
| title_short | Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic |
| title_sort | lower nk cell numbers in children with untreated juvenile dermatomyositis during the covid 19 pandemic |
| topic | Juvenile dermatomyositis NK Cells COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S2772613423000070 |
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