Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

BackgroundThe proprotein convertase subtilisin/kexin type 9 (PCSK9) has been implicated in the pathogenesis of inflammatory diseases. We sought to investigate the role of PCSK9 in the pathogenesis of Graves’ orbitopathy (GO) and whether it may be a legitimate target for treatment.MethodsThe PCSK9 wa...

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Bibliographic Details
Main Authors: Ga Eun Lee, Jinjoo Kim, Jihei Sara Lee, JaeSang Ko, Eun Jig Lee, Jin Sook Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Endocrinology
Subjects:
adipogenesis
Graves’ orbitopathy
inflammation
oxidative stress
proprotein convertase subtilisin/kexin type 9
PCSK9
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.607144/full

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