Bullous pemphigoid and radiotherapy: case report and literature review update
INTROUDCTION Bullous pemphigoid (BP) is a common autoimmune bullous disease generally occurring in elderly patients. Itchy and tense blisters on normal skin or erythematous and edematous lesions on the trunk and extremities usually characterize BP. Trigger factors are still unclear while several cas...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-12-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/9170 |
| _version_ | 1818893298046074880 |
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| author | Antonio Piras Bruno Fionda Antonella Sanfratello Andrea D'Aviero Giovanni Sortino Gianfranco Pernice Luca Boldrini Tommaso Angileri Antonino Daidone |
| author_facet | Antonio Piras Bruno Fionda Antonella Sanfratello Andrea D'Aviero Giovanni Sortino Gianfranco Pernice Luca Boldrini Tommaso Angileri Antonino Daidone |
| author_sort | Antonio Piras |
| collection | DOAJ |
| description | INTROUDCTION Bullous pemphigoid (BP) is a common autoimmune bullous disease generally occurring in elderly patients. Itchy and tense blisters on normal skin or erythematous and edematous lesions on the trunk and extremities usually characterize BP. Trigger factors are still unclear while several case reports suggest a potential role of radiotherapy (RT) as BP trigger for disease onset or recrudescence. A review was performed in order to provide an update of literature. A case report of a patient affected by BP undergoing two radiotherapy courses for a primary breast cancer was also reported.
MATERIALS AND METHODS A comprehensive review of the published literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The review included studies describing BP and its relationships with RT treatments.
RESULTS A total of 13 articles were reviewed. Studies characteristics analysis resulted in eleven case reports, one case series and one large-scale case–control study.
CONCLUSIONS Literature update confirms the existence of a reasonable connection between RT and BP. Case report showed that a multidisciplinary management seems to assure the feasibility of RT in patients affected by BP, not depriving them of standard therapeutic opportunities. |
| first_indexed | 2024-12-19T18:10:22Z |
| format | Article |
| id | doaj.art-41c4d97f136a4827a87a8a05f6d5f3d1 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-19T18:10:22Z |
| publishDate | 2021-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-41c4d97f136a4827a87a8a05f6d5f3d12022-12-21T20:11:19ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062021-12-0110.4081/dr.2021.9170Bullous pemphigoid and radiotherapy: case report and literature review updateAntonio Piras0Bruno Fionda1Antonella Sanfratello2Andrea D'Aviero3Giovanni Sortino4Gianfranco Pernice5Luca Boldrini6Tommaso Angileri7Antonino Daidone8UO Radioterapia Oncologica, Villa Santa Teresa, Bagheria, PalermoUOC Radioterapia Oncologica - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, RomeUniversità degli Studi di Palermo, Radioterapia Oncologica, PalermoFondazione Policlinico Universitario Agostino Gemelli IRCCSUO Oncologia, Fondazione Istituto G. Giglio, Cefalù, PalermoUO Oncologia, Fondazione Istituto G. Giglio, Cefalù, PalermoUOC Radioterapia Oncologica - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, RomeUO Radiologia, Villa Santa Teresa, Bagheria, PalermoUO Radioterapia Oncologica, Villa Santa Teresa, Bagheria, PalermoINTROUDCTION Bullous pemphigoid (BP) is a common autoimmune bullous disease generally occurring in elderly patients. Itchy and tense blisters on normal skin or erythematous and edematous lesions on the trunk and extremities usually characterize BP. Trigger factors are still unclear while several case reports suggest a potential role of radiotherapy (RT) as BP trigger for disease onset or recrudescence. A review was performed in order to provide an update of literature. A case report of a patient affected by BP undergoing two radiotherapy courses for a primary breast cancer was also reported. MATERIALS AND METHODS A comprehensive review of the published literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The review included studies describing BP and its relationships with RT treatments. RESULTS A total of 13 articles were reviewed. Studies characteristics analysis resulted in eleven case reports, one case series and one large-scale case–control study. CONCLUSIONS Literature update confirms the existence of a reasonable connection between RT and BP. Case report showed that a multidisciplinary management seems to assure the feasibility of RT in patients affected by BP, not depriving them of standard therapeutic opportunities.https://www.pagepress.org/journals/index.php/dr/article/view/9170Bullous pemphigoid, Radiotherapy, Review, Personalized medicine. |
| spellingShingle | Antonio Piras Bruno Fionda Antonella Sanfratello Andrea D'Aviero Giovanni Sortino Gianfranco Pernice Luca Boldrini Tommaso Angileri Antonino Daidone Bullous pemphigoid and radiotherapy: case report and literature review update Dermatology Reports Bullous pemphigoid, Radiotherapy, Review, Personalized medicine. |
| title | Bullous pemphigoid and radiotherapy: case report and literature review update |
| title_full | Bullous pemphigoid and radiotherapy: case report and literature review update |
| title_fullStr | Bullous pemphigoid and radiotherapy: case report and literature review update |
| title_full_unstemmed | Bullous pemphigoid and radiotherapy: case report and literature review update |
| title_short | Bullous pemphigoid and radiotherapy: case report and literature review update |
| title_sort | bullous pemphigoid and radiotherapy case report and literature review update |
| topic | Bullous pemphigoid, Radiotherapy, Review, Personalized medicine. |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/9170 |
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