An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways
The nervous system plays a leading role in the regulation of physiological functions and activities in the body. However, a variety of diseases related to the nervous system have a serious impact on human health. It is increasingly clear that neurological diseases are multifactorial pathological pro...
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/2878 |
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| author | Xiangwen Tang Peng Deng Yizhen Jiang Lingling Zhang Yuqing He Hao Yang |
| author_facet | Xiangwen Tang Peng Deng Yizhen Jiang Lingling Zhang Yuqing He Hao Yang |
| author_sort | Xiangwen Tang |
| collection | DOAJ |
| description | The nervous system plays a leading role in the regulation of physiological functions and activities in the body. However, a variety of diseases related to the nervous system have a serious impact on human health. It is increasingly clear that neurological diseases are multifactorial pathological processes involving multiple cellular systems, and the onset of these diseases usually involves a diverse array of molecular mechanisms. Unfortunately, no effective therapy exists to slow down the progression or prevent the development of diseases only through the regulation of a single factor. To this end, it is pivotal to seek an ideal therapeutic approach for challenging the complicated pathological process to achieve effective treatment. In recent years, fisetin, a kind of flavonoid widely existing in fruits, vegetables and other plants, has shown numerous interesting biological activities with clinical potentials including anti-inflammatory, antioxidant and neurotrophic effects. In addition, fisetin has been reported to have diverse pharmacological properties and neuroprotective potentials against various neurological diseases. The neuroprotective effects were ascribed to its unique biological properties and multiple clinical pharmacological activities associated with the treatment of different neurological disorders. In this review, we summarize recent research progress regarding the neuroprotective potential of fisetin and the underlying signaling pathways of the treatment of several neurological diseases. |
| first_indexed | 2024-03-09T17:00:25Z |
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| id | doaj.art-41c4f1a5d1b049b8817573fcd74eebcf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:00:25Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-41c4f1a5d1b049b8817573fcd74eebcf2023-11-24T14:30:34ZengMDPI AGBiomedicines2227-90592023-10-011111287810.3390/biomedicines11112878An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling PathwaysXiangwen Tang0Peng Deng1Yizhen Jiang2Lingling Zhang3Yuqing He4Hao Yang5Translational Medicine Center, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaBasic Medical School Academy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, ChinaBasic Medical School Academy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, ChinaTranslational Medicine Center, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, ChinaTranslational Medicine Center, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaThe nervous system plays a leading role in the regulation of physiological functions and activities in the body. However, a variety of diseases related to the nervous system have a serious impact on human health. It is increasingly clear that neurological diseases are multifactorial pathological processes involving multiple cellular systems, and the onset of these diseases usually involves a diverse array of molecular mechanisms. Unfortunately, no effective therapy exists to slow down the progression or prevent the development of diseases only through the regulation of a single factor. To this end, it is pivotal to seek an ideal therapeutic approach for challenging the complicated pathological process to achieve effective treatment. In recent years, fisetin, a kind of flavonoid widely existing in fruits, vegetables and other plants, has shown numerous interesting biological activities with clinical potentials including anti-inflammatory, antioxidant and neurotrophic effects. In addition, fisetin has been reported to have diverse pharmacological properties and neuroprotective potentials against various neurological diseases. The neuroprotective effects were ascribed to its unique biological properties and multiple clinical pharmacological activities associated with the treatment of different neurological disorders. In this review, we summarize recent research progress regarding the neuroprotective potential of fisetin and the underlying signaling pathways of the treatment of several neurological diseases.https://www.mdpi.com/2227-9059/11/11/2878fisetinneurological diseasesflavonoidneuroprotectionnerve injury |
| spellingShingle | Xiangwen Tang Peng Deng Yizhen Jiang Lingling Zhang Yuqing He Hao Yang An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways Biomedicines fisetin neurological diseases flavonoid neuroprotection nerve injury |
| title | An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways |
| title_full | An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways |
| title_fullStr | An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways |
| title_full_unstemmed | An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways |
| title_short | An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways |
| title_sort | overview of recent advances in the neuroprotective potentials of fisetin against diverse insults in neurological diseases and the underlying signaling pathways |
| topic | fisetin neurological diseases flavonoid neuroprotection nerve injury |
| url | https://www.mdpi.com/2227-9059/11/11/2878 |
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