Nanosphere pharmacodynamics improves safety of immunostimulatory cytokine therapy

Nanosphere pharmacodynamics improves safety of immunostimulatory cytokine therapy

Summary: Systemic administration of interleukin (IL)-12 induces potent anti-tumor immune responses in preclinical cancer models through the systemic activation of effector immune cells and release of proinflammatory cytokines. IL-12-loaded PLGA nanospheres (IL12ns) are hypothesized to improve therap...

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Bibliographic Details
Main Authors:	Ryan A. Lacinski, Sebastian A. Dziadowicz, Amanda Stewart, Edwin Chaharbakhshi, Halima Akhter, John J. Pisquiy, Jack H. Victory, Joshua B. Hardham, Claude Chew, Alyson Prorock, Yongde Bao, Katia Sol-Church, Gerald R. Hobbs, Edwin Klein, Michael A. Nalesnik, Gangqing Hu, Ana de Oliveira, Stell P. Santiago, Brock A. Lindsey
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Series:	iScience
Subjects:	Health sciences Immunology Pharmaceutical science Pharmaceutical compounds formulation Drug dispensing Pharmacology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224000579

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