Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro exp...
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| Format: | Article |
| Language: | English |
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BMC
2001-01-01
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| Series: | Biological Research |
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011 |
| _version_ | 1828487137126776832 |
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| author | JIMENA CUENCA CLAUDIO A. PÉREZ ADAM J. AGUIRRE IRENE SCHIATTINO J. CARLOS AGUILLÓN |
| author_facet | JIMENA CUENCA CLAUDIO A. PÉREZ ADAM J. AGUIRRE IRENE SCHIATTINO J. CARLOS AGUILLÓN |
| author_sort | JIMENA CUENCA |
| collection | DOAJ |
| description | Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases. |
| first_indexed | 2024-12-11T09:45:20Z |
| format | Article |
| id | doaj.art-41c5b6147c0c4465be2bdf46749df5bc |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-12-11T09:45:20Z |
| publishDate | 2001-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-41c5b6147c0c4465be2bdf46749df5bc2022-12-22T01:12:33ZengBMCBiological Research0716-97600717-62872001-01-01343-4237241Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean populationJIMENA CUENCACLAUDIO A. PÉREZADAM J. AGUIRREIRENE SCHIATTINOJ. CARLOS AGUILLÓNSeveral single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011 |
| spellingShingle | JIMENA CUENCA CLAUDIO A. PÉREZ ADAM J. AGUIRRE IRENE SCHIATTINO J. CARLOS AGUILLÓN Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population Biological Research |
| title | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population |
| title_full | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population |
| title_fullStr | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population |
| title_full_unstemmed | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population |
| title_short | Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population |
| title_sort | genetic polymorphism at position 308 in the promoter region of the tumor necrosis factor tnf implications of its allelic distribution on susceptibility or resistance to diseases in the chilean population |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011 |
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