A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders
Abstract Given the psychic strain patients experience in the intensive care unit (ICU), a potential risk of mental disorders has been suggested. However, the effects of intensive care treatment per se are unknown. We investigated whether the level of intensive care treatments is an independent risk...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55102-9 |
| _version_ | 1797274711718100992 |
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| author | Rasmus Mossberg Björn Ahlström Miklos Lipcsey |
| author_facet | Rasmus Mossberg Björn Ahlström Miklos Lipcsey |
| author_sort | Rasmus Mossberg |
| collection | DOAJ |
| description | Abstract Given the psychic strain patients experience in the intensive care unit (ICU), a potential risk of mental disorders has been suggested. However, the effects of intensive care treatment per se are unknown. We investigated whether the level of intensive care treatments is an independent risk factor for developing long-term mental disorders after intensive care. In a national cohort of adult ICU patients we combined data on diagnoses, treatment, and causes of death. We defined extensive ICU treatment as being treated with invasive ventilation for > 24 h, continuous renal replacement therapy, or both. The primary outcome was incident mental disorder 1 year after ICU admission. Extensive ICU treatment was found to be associated with a decreased risk of developing a mental disorder ≥ 1 year after ICU admission (HR 0.90, 95% CI 0.82–0.99, p = 0.04), and increasing severity of acute illness (HR 1.18, 95% CI 1.06–1.32, p < 0.001) were associated with an increased risk of mental disorders. Because death acted as a competing risk for mental illness, mortality might help explain the apparent protective effect of extensive ICU care. Trial registration Clinical Trials Registry (Identification number NCT05137977). Registered 16 November 2021. As a registry trial the patients were already included at the trial registration i.e. it was retrospectively registered. |
| first_indexed | 2024-03-07T15:02:12Z |
| format | Article |
| id | doaj.art-41c6f73501ed4dbab85f348df5472b98 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:12Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-41c6f73501ed4dbab85f348df5472b982024-03-05T19:03:55ZengNature PortfolioScientific Reports2045-23222024-02-011411910.1038/s41598-024-55102-9A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disordersRasmus Mossberg0Björn Ahlström1Miklos Lipcsey2Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala UniversityAnesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala UniversityAnesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala UniversityAbstract Given the psychic strain patients experience in the intensive care unit (ICU), a potential risk of mental disorders has been suggested. However, the effects of intensive care treatment per se are unknown. We investigated whether the level of intensive care treatments is an independent risk factor for developing long-term mental disorders after intensive care. In a national cohort of adult ICU patients we combined data on diagnoses, treatment, and causes of death. We defined extensive ICU treatment as being treated with invasive ventilation for > 24 h, continuous renal replacement therapy, or both. The primary outcome was incident mental disorder 1 year after ICU admission. Extensive ICU treatment was found to be associated with a decreased risk of developing a mental disorder ≥ 1 year after ICU admission (HR 0.90, 95% CI 0.82–0.99, p = 0.04), and increasing severity of acute illness (HR 1.18, 95% CI 1.06–1.32, p < 0.001) were associated with an increased risk of mental disorders. Because death acted as a competing risk for mental illness, mortality might help explain the apparent protective effect of extensive ICU care. Trial registration Clinical Trials Registry (Identification number NCT05137977). Registered 16 November 2021. As a registry trial the patients were already included at the trial registration i.e. it was retrospectively registered.https://doi.org/10.1038/s41598-024-55102-9Mental disordersCritical illnessIntensive care unitsEpidemiologyRisk factors |
| spellingShingle | Rasmus Mossberg Björn Ahlström Miklos Lipcsey A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders Scientific Reports Mental disorders Critical illness Intensive care units Epidemiology Risk factors |
| title | A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| title_full | A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| title_fullStr | A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| title_full_unstemmed | A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| title_short | A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| title_sort | nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders |
| topic | Mental disorders Critical illness Intensive care units Epidemiology Risk factors |
| url | https://doi.org/10.1038/s41598-024-55102-9 |
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