The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1127358/full |
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| author | Aliakbar Hasankhani Abolfazl Bahrami Abolfazl Bahrami Bahareh Tavakoli-Far Bahareh Tavakoli-Far Setare Iranshahi Farnaz Ghaemi Majid Reza Akbarizadeh Ali H. Amin Bahman Abedi Kiasari Alireza Mohammadzadeh Shabestari Alireza Mohammadzadeh Shabestari |
| author_facet | Aliakbar Hasankhani Abolfazl Bahrami Abolfazl Bahrami Bahareh Tavakoli-Far Bahareh Tavakoli-Far Setare Iranshahi Farnaz Ghaemi Majid Reza Akbarizadeh Ali H. Amin Bahman Abedi Kiasari Alireza Mohammadzadeh Shabestari Alireza Mohammadzadeh Shabestari |
| author_sort | Aliakbar Hasankhani |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled inflammatory responses in the host, ultimately leading to hyperinflammation or cytokine storm. Indeed, cytokine storm is a hallmark of SARS-CoV-2 immunopathogenesis, directly related to the severity of the disease and mortality in COVID-19 patients. Considering the lack of any definitive treatment for COVID-19, targeting key inflammatory factors to regulate the inflammatory response in COVID-19 patients could be a fundamental step to developing effective therapeutic strategies against SARS-CoV-2 infection. Currently, in addition to well-defined metabolic actions, especially lipid metabolism and glucose utilization, there is growing evidence of a central role of the ligand-dependent nuclear receptors and peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARβ/δ, and PPARγ in the control of inflammatory signals in various human inflammatory diseases. This makes them attractive targets for developing therapeutic approaches to control/suppress the hyperinflammatory response in patients with severe COVID-19. In this review, we (1) investigate the anti-inflammatory mechanisms mediated by PPARs and their ligands during SARS-CoV-2 infection, and (2) on the basis of the recent literature, highlight the importance of PPAR subtypes for the development of promising therapeutic approaches against the cytokine storm in severe COVID-19 patients. |
| first_indexed | 2024-04-10T09:41:53Z |
| format | Article |
| id | doaj.art-41c77ebcd8ae4991874106b6c5731ec2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T09:41:53Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-41c77ebcd8ae4991874106b6c5731ec22023-02-17T07:44:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11273581127358The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapyAliakbar Hasankhani0Abolfazl Bahrami1Abolfazl Bahrami2Bahareh Tavakoli-Far3Bahareh Tavakoli-Far4Setare Iranshahi5Farnaz Ghaemi6Majid Reza Akbarizadeh7Ali H. Amin8Bahman Abedi Kiasari9Alireza Mohammadzadeh Shabestari10Alireza Mohammadzadeh Shabestari11Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, IranDepartment of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, IranBiomedical Center for Systems Biology Science Munich, Ludwig-Maximilians-University, Munich, GermanyDietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, IranDepartment of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, IranSchool of Pharmacy, Shahid Beheshty University of Medical Sciences, Tehran, IranDepartment of Biochemistry, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Pediatric, School of Medicine, Amir al momenin Hospital, Zabol University of Medical Sciences, Zabol, IranZoology Department, Faculty of Science, Mansoura University, Mansoura, EgyptVirology Department, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran0Department of Dental Surgery, Mashhad University of Medical Sciences, Mashhad, Iran1Khorasan Covid-19 Scientific Committee, Mashhad, IranCoronavirus disease 2019 (COVID-19) is a severe respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the lower and upper respiratory tract in humans. SARS-CoV-2 infection is associated with the induction of a cascade of uncontrolled inflammatory responses in the host, ultimately leading to hyperinflammation or cytokine storm. Indeed, cytokine storm is a hallmark of SARS-CoV-2 immunopathogenesis, directly related to the severity of the disease and mortality in COVID-19 patients. Considering the lack of any definitive treatment for COVID-19, targeting key inflammatory factors to regulate the inflammatory response in COVID-19 patients could be a fundamental step to developing effective therapeutic strategies against SARS-CoV-2 infection. Currently, in addition to well-defined metabolic actions, especially lipid metabolism and glucose utilization, there is growing evidence of a central role of the ligand-dependent nuclear receptors and peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARβ/δ, and PPARγ in the control of inflammatory signals in various human inflammatory diseases. This makes them attractive targets for developing therapeutic approaches to control/suppress the hyperinflammatory response in patients with severe COVID-19. In this review, we (1) investigate the anti-inflammatory mechanisms mediated by PPARs and their ligands during SARS-CoV-2 infection, and (2) on the basis of the recent literature, highlight the importance of PPAR subtypes for the development of promising therapeutic approaches against the cytokine storm in severe COVID-19 patients.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1127358/fullSARS-CoV-2cytokine stormPPARshyperinflammationCOVID-19 therapy, |
| spellingShingle | Aliakbar Hasankhani Abolfazl Bahrami Abolfazl Bahrami Bahareh Tavakoli-Far Bahareh Tavakoli-Far Setare Iranshahi Farnaz Ghaemi Majid Reza Akbarizadeh Ali H. Amin Bahman Abedi Kiasari Alireza Mohammadzadeh Shabestari Alireza Mohammadzadeh Shabestari The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy Frontiers in Immunology SARS-CoV-2 cytokine storm PPARs hyperinflammation COVID-19 therapy, |
| title | The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy |
| title_full | The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy |
| title_fullStr | The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy |
| title_full_unstemmed | The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy |
| title_short | The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy |
| title_sort | role of peroxisome proliferator activated receptors in the modulation of hyperinflammation induced by sars cov 2 infection a perspective for covid 19 therapy |
| topic | SARS-CoV-2 cytokine storm PPARs hyperinflammation COVID-19 therapy, |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1127358/full |
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