Intracellular DNA sensing by neutrophils and amplification of the innate immune response
As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production of ROS, and the secretion...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1208137/full |
| _version_ | 1797785229424852992 |
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| author | Arun K. Mankan Paulina Czajka-Francuz Maria Prendes Sriram Ramanan Marcin Koziej Laura Vidal Kamal S. Saini Kamal S. Saini |
| author_facet | Arun K. Mankan Paulina Czajka-Francuz Maria Prendes Sriram Ramanan Marcin Koziej Laura Vidal Kamal S. Saini Kamal S. Saini |
| author_sort | Arun K. Mankan |
| collection | DOAJ |
| description | As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production of ROS, and the secretion of neutrophil extracellular traps (NETs). Only recently, the ability of neutrophils to sense and respond to pathogen-associated molecular patterns is being appreciated. This review brings together the current information about the intracellular recognition of DNA by neutrophils and proposes models of signal amplification in immune response. Finally, the clinical relevance of DNA sensing by neutrophils in infectious and non-infectious diseases including malignancy are also discussed. |
| first_indexed | 2024-03-13T00:52:04Z |
| format | Article |
| id | doaj.art-41c8b3f0a6b84fc79d1336dc6914198e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T00:52:04Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-41c8b3f0a6b84fc79d1336dc6914198e2023-07-07T12:28:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12081371208137Intracellular DNA sensing by neutrophils and amplification of the innate immune responseArun K. Mankan0Paulina Czajka-Francuz1Maria Prendes2Sriram Ramanan3Marcin Koziej4Laura Vidal5Kamal S. Saini6Kamal S. Saini7Fortrea, Inc., Durham, NC, United StatesFortrea, Inc., Durham, NC, United StatesLabcorp Drug Development Inc., Princeton, NJ, United StatesLabcorp Drug Development Inc., Princeton, NJ, United StatesFortrea, Inc., Durham, NC, United StatesFortrea, Inc., Durham, NC, United StatesFortrea, Inc., Durham, NC, United StatesAddenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United KingdomAs the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by neutrophils are phagocytosis, the action of microbicide granules, the production of ROS, and the secretion of neutrophil extracellular traps (NETs). Only recently, the ability of neutrophils to sense and respond to pathogen-associated molecular patterns is being appreciated. This review brings together the current information about the intracellular recognition of DNA by neutrophils and proposes models of signal amplification in immune response. Finally, the clinical relevance of DNA sensing by neutrophils in infectious and non-infectious diseases including malignancy are also discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1208137/fullneutrophilsDNA sensing pathwaysAIM2SOX2cGASCancer |
| spellingShingle | Arun K. Mankan Paulina Czajka-Francuz Maria Prendes Sriram Ramanan Marcin Koziej Laura Vidal Kamal S. Saini Kamal S. Saini Intracellular DNA sensing by neutrophils and amplification of the innate immune response Frontiers in Immunology neutrophils DNA sensing pathways AIM2 SOX2 cGAS Cancer |
| title | Intracellular DNA sensing by neutrophils and amplification of the innate immune response |
| title_full | Intracellular DNA sensing by neutrophils and amplification of the innate immune response |
| title_fullStr | Intracellular DNA sensing by neutrophils and amplification of the innate immune response |
| title_full_unstemmed | Intracellular DNA sensing by neutrophils and amplification of the innate immune response |
| title_short | Intracellular DNA sensing by neutrophils and amplification of the innate immune response |
| title_sort | intracellular dna sensing by neutrophils and amplification of the innate immune response |
| topic | neutrophils DNA sensing pathways AIM2 SOX2 cGAS Cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1208137/full |
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