Evaluating hydrogenated nickel-titanium alloy for orthopedic implant
Nickel-titanium (NiTi) alloys are widely used in orthopedic implants for their good biocompatibility and mechanical properties. They are also applied for hydrogen storage capacity in energy application. Here we evaluated the use of NiTi alloys as carriers for delivering hydrogen molecules to wound s...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422003313 |
| _version_ | 1818773616290955264 |
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| author | Thu-Trang Nguyen Chih-Chien Hu Bo-Yan Chou Ching-Yi Chou Guan-Yi Lin Yu-Chen Hu Yan-Lin Chen Wei-Tung Hsu Zi-Sheng Lin Yueh-Lien Lee Chih-Hsuan Chen Hung-Wei Yen Ren-Jei Chung |
| author_facet | Thu-Trang Nguyen Chih-Chien Hu Bo-Yan Chou Ching-Yi Chou Guan-Yi Lin Yu-Chen Hu Yan-Lin Chen Wei-Tung Hsu Zi-Sheng Lin Yueh-Lien Lee Chih-Hsuan Chen Hung-Wei Yen Ren-Jei Chung |
| author_sort | Thu-Trang Nguyen |
| collection | DOAJ |
| description | Nickel-titanium (NiTi) alloys are widely used in orthopedic implants for their good biocompatibility and mechanical properties. They are also applied for hydrogen storage capacity in energy application. Here we evaluated the use of NiTi alloys as carriers for delivering hydrogen molecules to wound sites, where these hydrogen molecules could be released to reduce the free radicals and inhibit the inflammatory reactions at these sites. The results of the XRD characterization, cyclic voltammetry, and thermal desorption analyses showed that the NiTi alloys used in this study could effectively carry hydrogen molecules after treating with cathodic hydrogen charging method. After hydrogen charging, the results of nano-indentation test revealed that the Young's modulus for these materials decreased from 81.45 GPa to 62.15 GPa, and its hardness decreased from 5.33 GPa to 4.50 GPa, which could help to improve the biocompatibility; and the water contact angle decreased from 75.04° to 63.83°, which is beneficial for cellular attachment. The results of the in vitro and in vivo study show that the use of hydrogen charged NiTi alloys could lead to higher cellular viability in human osteosarcoma cells (MG63), mouse fibroblasts (L929), and rat bone mesenchymal stem cells (BMSCs) and would significantly reduce inflammation. |
| first_indexed | 2024-12-18T10:28:05Z |
| format | Article |
| id | doaj.art-41c9f9ad8716439a9af27f2efaf08798 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-18T10:28:05Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-41c9f9ad8716439a9af27f2efaf087982022-12-21T21:10:55ZengElsevierJournal of Materials Research and Technology2238-78542022-05-011811151123Evaluating hydrogenated nickel-titanium alloy for orthopedic implantThu-Trang Nguyen0Chih-Chien Hu1Bo-Yan Chou2Ching-Yi Chou3Guan-Yi Lin4Yu-Chen Hu5Yan-Lin Chen6Wei-Tung Hsu7Zi-Sheng Lin8Yueh-Lien Lee9Chih-Hsuan Chen10Hung-Wei Yen11Ren-Jei Chung12Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanBone and Joint Research Center, Chang Gung Memorial Hospital, Linko, Taiwan; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Linko, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, TaiwanDepartment of Engineering Science and Ocean Engineerin, National Taiwan University, Taipei, TaiwanDepartment of Mechanical Engineering, National Taiwan University, Taipei, TaiwanDepartment of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan; Corresponding author.Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; Corresponding author.Nickel-titanium (NiTi) alloys are widely used in orthopedic implants for their good biocompatibility and mechanical properties. They are also applied for hydrogen storage capacity in energy application. Here we evaluated the use of NiTi alloys as carriers for delivering hydrogen molecules to wound sites, where these hydrogen molecules could be released to reduce the free radicals and inhibit the inflammatory reactions at these sites. The results of the XRD characterization, cyclic voltammetry, and thermal desorption analyses showed that the NiTi alloys used in this study could effectively carry hydrogen molecules after treating with cathodic hydrogen charging method. After hydrogen charging, the results of nano-indentation test revealed that the Young's modulus for these materials decreased from 81.45 GPa to 62.15 GPa, and its hardness decreased from 5.33 GPa to 4.50 GPa, which could help to improve the biocompatibility; and the water contact angle decreased from 75.04° to 63.83°, which is beneficial for cellular attachment. The results of the in vitro and in vivo study show that the use of hydrogen charged NiTi alloys could lead to higher cellular viability in human osteosarcoma cells (MG63), mouse fibroblasts (L929), and rat bone mesenchymal stem cells (BMSCs) and would significantly reduce inflammation.http://www.sciencedirect.com/science/article/pii/S2238785422003313Nickel-titanium alloysOrthopedic implantsHydrogen storageCathodic hydrogen charging methodFree radicals |
| spellingShingle | Thu-Trang Nguyen Chih-Chien Hu Bo-Yan Chou Ching-Yi Chou Guan-Yi Lin Yu-Chen Hu Yan-Lin Chen Wei-Tung Hsu Zi-Sheng Lin Yueh-Lien Lee Chih-Hsuan Chen Hung-Wei Yen Ren-Jei Chung Evaluating hydrogenated nickel-titanium alloy for orthopedic implant Journal of Materials Research and Technology Nickel-titanium alloys Orthopedic implants Hydrogen storage Cathodic hydrogen charging method Free radicals |
| title | Evaluating hydrogenated nickel-titanium alloy for orthopedic implant |
| title_full | Evaluating hydrogenated nickel-titanium alloy for orthopedic implant |
| title_fullStr | Evaluating hydrogenated nickel-titanium alloy for orthopedic implant |
| title_full_unstemmed | Evaluating hydrogenated nickel-titanium alloy for orthopedic implant |
| title_short | Evaluating hydrogenated nickel-titanium alloy for orthopedic implant |
| title_sort | evaluating hydrogenated nickel titanium alloy for orthopedic implant |
| topic | Nickel-titanium alloys Orthopedic implants Hydrogen storage Cathodic hydrogen charging method Free radicals |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422003313 |
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