A Review of DUSP26: Structure, Regulation and Relevance in Human Disease
Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human diseases due to deregulation of key pathways, most n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/776 |
| _version_ | 1797411752411922432 |
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| author | Elliott M. Thompson Andrew W. Stoker |
| author_facet | Elliott M. Thompson Andrew W. Stoker |
| author_sort | Elliott M. Thompson |
| collection | DOAJ |
| description | Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human diseases due to deregulation of key pathways, most notably the MAP kinase (MAPK) cascades. Dual specificity phosphatase 26 (DUSP26) is an atypical DUSP with a range of physiological substrates including the MAPKs. The residues that govern DUSP26 substrate specificity are yet to be determined; however, recent evidence suggests that interactions with a binding partner may be required for DUSP26 catalytic activity. DUSP26 is heavily implicated in cancer where, akin to other DUSPs, it displays both tumour-suppressive and -promoting properties, depending on the context. Here we review DUSP26 by evaluating its transcriptional patterns, protein crystallographic structure and substrate binding, as well as its physiological role(s) and binding partners, its role in human disease and the development of DUSP26 inhibitors. |
| first_indexed | 2024-03-09T04:50:43Z |
| format | Article |
| id | doaj.art-41cc279e1627484eb7e7d54409410c9c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:50:43Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41cc279e1627484eb7e7d54409410c9c2023-12-03T13:10:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122277610.3390/ijms22020776A Review of DUSP26: Structure, Regulation and Relevance in Human DiseaseElliott M. Thompson0Andrew W. Stoker1Developmental Biology & Cancer Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UKDevelopmental Biology & Cancer Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UKDual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human diseases due to deregulation of key pathways, most notably the MAP kinase (MAPK) cascades. Dual specificity phosphatase 26 (DUSP26) is an atypical DUSP with a range of physiological substrates including the MAPKs. The residues that govern DUSP26 substrate specificity are yet to be determined; however, recent evidence suggests that interactions with a binding partner may be required for DUSP26 catalytic activity. DUSP26 is heavily implicated in cancer where, akin to other DUSPs, it displays both tumour-suppressive and -promoting properties, depending on the context. Here we review DUSP26 by evaluating its transcriptional patterns, protein crystallographic structure and substrate binding, as well as its physiological role(s) and binding partners, its role in human disease and the development of DUSP26 inhibitors.https://www.mdpi.com/1422-0067/22/2/776dual specificity phosphataseMAP kinase phosphatasecancerneuroblastomaphosphatase inhibitor |
| spellingShingle | Elliott M. Thompson Andrew W. Stoker A Review of DUSP26: Structure, Regulation and Relevance in Human Disease International Journal of Molecular Sciences dual specificity phosphatase MAP kinase phosphatase cancer neuroblastoma phosphatase inhibitor |
| title | A Review of DUSP26: Structure, Regulation and Relevance in Human Disease |
| title_full | A Review of DUSP26: Structure, Regulation and Relevance in Human Disease |
| title_fullStr | A Review of DUSP26: Structure, Regulation and Relevance in Human Disease |
| title_full_unstemmed | A Review of DUSP26: Structure, Regulation and Relevance in Human Disease |
| title_short | A Review of DUSP26: Structure, Regulation and Relevance in Human Disease |
| title_sort | review of dusp26 structure regulation and relevance in human disease |
| topic | dual specificity phosphatase MAP kinase phosphatase cancer neuroblastoma phosphatase inhibitor |
| url | https://www.mdpi.com/1422-0067/22/2/776 |
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