Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice
Insufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-09-01
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| Series: | Sleep Science |
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| Online Access: | https://sleepscience.org.br/details/3333/en-US/exercise-modifies-lipid-and-glucose-metabolism-alterations-induced-by-sleep-deprivation-in-mice |
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| author | Bruna Rafaele Diogenes da Silva Paulo Iury Gomes Nunes Flavia Almeida Santos Pedro Felipe Carvalhedo de Bruin Veralice Meireles Sales de Bruin |
| author_facet | Bruna Rafaele Diogenes da Silva Paulo Iury Gomes Nunes Flavia Almeida Santos Pedro Felipe Carvalhedo de Bruin Veralice Meireles Sales de Bruin |
| author_sort | Bruna Rafaele Diogenes da Silva |
| collection | DOAJ |
| description | Insufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effects of exercise (EX), SD and EX before SD. (EX+SD) on lipid and glucose metabolism were evaluated. Swiss mice were assigned to 4 groups (N=12, each) control, exercise (EX, 8 weeks, 1-hour of treadmill/9cm/s, 5x/week, from noon to 1:00 p.m.), SD (SD-72h, multiple platforms method), and exercise before SD (EX+SD). Exercise increased blood glucose, lactate and triglycerides (p<0.05). Both, SD and EX+SD reduced blood triglycerides (p<0.05). EX increased VLDL and reduced LDL; conversely, SD and EX+SD reduced VLDL and increased LDL. Hepatic triglycerides were markedly reduced by SD (p<0.05) and this was prevented by previous exercise (EX+SD). In summary, exercise improved essential cholesterol fractions and exercise before SD increased hepatic cholesterol and prevented hepatic triglycerides depletion. |
| first_indexed | 2024-03-08T17:53:00Z |
| format | Article |
| id | doaj.art-41cc94da07e440a7a66e7db851ece60e |
| institution | Directory Open Access Journal |
| issn | 1984-0659 1984-0063 |
| language | English |
| last_indexed | 2024-03-08T17:53:00Z |
| publishDate | 2022-09-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj.art-41cc94da07e440a7a66e7db851ece60e2024-01-02T06:37:50ZengThieme Revinter Publicações Ltda.Sleep Science1984-06591984-00632022-09-01150334735010.5935/1984-0063.20220061Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in miceBruna Rafaele Diogenes da Silva0Paulo Iury Gomes Nunes1Flavia Almeida Santos2Pedro Felipe Carvalhedo de Bruin3Veralice Meireles Sales de Bruin4Federal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - BrazilFederal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - BrazilFederal University of Ceará, Graduate Program in Pharmacology, Department of Physiology and Pharmacology - Fortaleza - Ceará - BrazilFederal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - BrazilFederal University of Ceará, Graduate Program in Medical Sciences, Department of Clinical Medicine - Fortaleza - Ceará - BrazilInsufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effects of exercise (EX), SD and EX before SD. (EX+SD) on lipid and glucose metabolism were evaluated. Swiss mice were assigned to 4 groups (N=12, each) control, exercise (EX, 8 weeks, 1-hour of treadmill/9cm/s, 5x/week, from noon to 1:00 p.m.), SD (SD-72h, multiple platforms method), and exercise before SD (EX+SD). Exercise increased blood glucose, lactate and triglycerides (p<0.05). Both, SD and EX+SD reduced blood triglycerides (p<0.05). EX increased VLDL and reduced LDL; conversely, SD and EX+SD reduced VLDL and increased LDL. Hepatic triglycerides were markedly reduced by SD (p<0.05) and this was prevented by previous exercise (EX+SD). In summary, exercise improved essential cholesterol fractions and exercise before SD increased hepatic cholesterol and prevented hepatic triglycerides depletion.https://sleepscience.org.br/details/3333/en-US/exercise-modifies-lipid-and-glucose-metabolism-alterations-induced-by-sleep-deprivation-in-micesleep deprivationexerciseglycogenlipidscholesterolliver. |
| spellingShingle | Bruna Rafaele Diogenes da Silva Paulo Iury Gomes Nunes Flavia Almeida Santos Pedro Felipe Carvalhedo de Bruin Veralice Meireles Sales de Bruin Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice Sleep Science sleep deprivation exercise glycogen lipids cholesterol liver. |
| title | Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| title_full | Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| title_fullStr | Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| title_full_unstemmed | Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| title_short | Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| title_sort | exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice |
| topic | sleep deprivation exercise glycogen lipids cholesterol liver. |
| url | https://sleepscience.org.br/details/3333/en-US/exercise-modifies-lipid-and-glucose-metabolism-alterations-induced-by-sleep-deprivation-in-mice |
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