<i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being
The altered patterns of a microbial population colonizing an organ are increasingly recognized as a relevant item in human disease pathogenesis. The female urogenital tract is no exception, as some vaginal microbiota patterns, named community state types (CSTs), and urinary tract microbiota patterns...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Microbiology Research |
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| Online Access: | https://www.mdpi.com/2036-7481/13/4/69 |
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| author | Alexander Bertuccioli Marco Cardinali Giordano Zonzini Massimiliano Cazzaniga Francesco Di Pierro |
| author_facet | Alexander Bertuccioli Marco Cardinali Giordano Zonzini Massimiliano Cazzaniga Francesco Di Pierro |
| author_sort | Alexander Bertuccioli |
| collection | DOAJ |
| description | The altered patterns of a microbial population colonizing an organ are increasingly recognized as a relevant item in human disease pathogenesis. The female urogenital tract is no exception, as some vaginal microbiota patterns, named community state types (CSTs), and urinary tract microbiota patterns, named urotypes (UTs), have been linked to viral, inflammatory, and gestational diseases. Treating these conditions is an issue, as antibiotic therapies alone are not always effective. <i>Lactobacillus crispatus</i> M247 is a strain with good intestinal and vaginal adhesion capability, combined with local antibacterial and anti-inflammatory properties; this strain also has proven nontransferable resistance to antibiotics commonly used in female genital tract infections, such as metronidazole. <i>Lactobacillus crispatus</i> M247 could, therefore, be considered as a potential add-on therapy to antibiotics in vaginal tract infections, with the aim to restore a favorable microbiota pattern. |
| first_indexed | 2024-03-09T16:04:59Z |
| format | Article |
| id | doaj.art-41cd7920d2644f3782e6cb6b503e3335 |
| institution | Directory Open Access Journal |
| issn | 2036-7481 |
| language | English |
| last_indexed | 2024-03-09T16:04:59Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microbiology Research |
| spelling | doaj.art-41cd7920d2644f3782e6cb6b503e33352023-11-24T16:42:57ZengMDPI AGMicrobiology Research2036-74812022-11-0113496397110.3390/microbiolres13040069<i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-BeingAlexander Bertuccioli0Marco Cardinali1Giordano Zonzini2Massimiliano Cazzaniga3Francesco Di Pierro4Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, ItalyDepartment of Internal Medicine, Infermi Hospital, AUSL Romagna, 47921 Rimini, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, ItalyScientific & Research Department, Velleja Research, 20125 Milano, ItalyScientific & Research Department, Velleja Research, 20125 Milano, ItalyThe altered patterns of a microbial population colonizing an organ are increasingly recognized as a relevant item in human disease pathogenesis. The female urogenital tract is no exception, as some vaginal microbiota patterns, named community state types (CSTs), and urinary tract microbiota patterns, named urotypes (UTs), have been linked to viral, inflammatory, and gestational diseases. Treating these conditions is an issue, as antibiotic therapies alone are not always effective. <i>Lactobacillus crispatus</i> M247 is a strain with good intestinal and vaginal adhesion capability, combined with local antibacterial and anti-inflammatory properties; this strain also has proven nontransferable resistance to antibiotics commonly used in female genital tract infections, such as metronidazole. <i>Lactobacillus crispatus</i> M247 could, therefore, be considered as a potential add-on therapy to antibiotics in vaginal tract infections, with the aim to restore a favorable microbiota pattern.https://www.mdpi.com/2036-7481/13/4/69<i>Lactobacillus crispatus</i> M247CST Ibacterial vaginosismetronidazolesulfamethoxazoleboric acid |
| spellingShingle | Alexander Bertuccioli Marco Cardinali Giordano Zonzini Massimiliano Cazzaniga Francesco Di Pierro <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being Microbiology Research <i>Lactobacillus crispatus</i> M247 CST I bacterial vaginosis metronidazole sulfamethoxazole boric acid |
| title | <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being |
| title_full | <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being |
| title_fullStr | <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being |
| title_full_unstemmed | <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being |
| title_short | <i>Lactobacillus crispatus</i> M247: Characteristics of a Precision Probiotic Instrument for Gynecological and Urinary Well-Being |
| title_sort | i lactobacillus crispatus i m247 characteristics of a precision probiotic instrument for gynecological and urinary well being |
| topic | <i>Lactobacillus crispatus</i> M247 CST I bacterial vaginosis metronidazole sulfamethoxazole boric acid |
| url | https://www.mdpi.com/2036-7481/13/4/69 |
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