Depression-Associated <i>Negr1</i> Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice

Depression-Associated <i>Negr1</i> Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice

In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (<i>NEGR1</i>) gene has been consistently linked with both depression and obesity. Although the linkage between <i>NEGR1</i> and depression is the strongest, evidence also suggests the invo...

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Bibliographic Details
Main Authors: Maria Kaare, Mohan Jayaram, Toomas Jagomäe, Katyayani Singh, Kalle Kilk, Kaie Mikheim, Marko Leevik, Este Leidmaa, Jane Varul, Helis Nõmm, Kristi Rähn, Tanel Visnapuu, Mario Plaas, Kersti Lilleväli, Michael K. E. Schäfer, Mari-Anne Philips, Eero Vasar
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Brain Sciences
Subjects:
Negr1
depression
dopamine
serotonin
genetic models
Online Access:https://www.mdpi.com/2076-3425/12/12/1696

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