The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass
Hepcidin-25 is suggested as a surrogate iron status marker in athletes who show exercise-induced anemia; however, the implications of hepcidin concentration in this population remain poorly understood. This study aimed to investigate the relationship between hepcidin and body fat levels in rugby foo...
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/2993 |
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| author | Shinsuke Nirengi Mami Fujibayashi Sachiko Furuno Shin Sukino Akiko Suganuma Yaeko Kawaguchi Yasuharu Kawase Kazuhiko Kotani Naoki Sakane |
| author_facet | Shinsuke Nirengi Mami Fujibayashi Sachiko Furuno Shin Sukino Akiko Suganuma Yaeko Kawaguchi Yasuharu Kawase Kazuhiko Kotani Naoki Sakane |
| author_sort | Shinsuke Nirengi |
| collection | DOAJ |
| description | Hepcidin-25 is suggested as a surrogate iron status marker in athletes who show exercise-induced anemia; however, the implications of hepcidin concentration in this population remain poorly understood. This study aimed to investigate the relationship between hepcidin and body fat levels in rugby football players. We included 40 male university rugby football players (RUG) and 40 non-athlete controls. All participants underwent an anthropometric analysis and blood testing that included both hepcidin-25 and ferritin levels. The hepcidin-25 level was slightly (11.6%, <i>p</i> = 0.50) higher, and the ferritin level was significantly (35.9%, <i>p</i> < 0.05) lower, in the RUG group than in controls. The hepcidin-25 to-ferritin ratio was significantly higher (62.5%, <i>p</i> < 0.05) in the RUG group. While significant U-shaped correlations were observed between the body fat and ferritin levels in both groups, the correlations between the hepcidin levels and fat mass index were significantly higher in the RUG group (RUG: <i>r</i> = 0.79, controls: <i>r</i> = 0.45). Notably, the RUG with the lower fat mass index group had a higher hepcidin-25 level, lower ferritin level, and then significantly higher hepcidin-25/ferritin ratio. The hepcidin-25/ferritin ratio may serve as a biomarker for iron status in RUG, especially RUG with lower fat mass. |
| first_indexed | 2024-03-10T07:21:05Z |
| format | Article |
| id | doaj.art-41cfe11188d44b3eb54818aaa53e8069 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:21:05Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-41cfe11188d44b3eb54818aaa53e80692023-11-22T14:35:41ZengMDPI AGNutrients2072-66432021-08-01139299310.3390/nu13092993The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat MassShinsuke Nirengi0Mami Fujibayashi1Sachiko Furuno2Shin Sukino3Akiko Suganuma4Yaeko Kawaguchi5Yasuharu Kawase6Kazuhiko Kotani7Naoki Sakane8Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanFaculty of Agriculture, Department of Food Science and Human Nutrition, Setsunan University, Osaka 573-0101, JapanFaculty of Agriculture, Department of Food Science and Human Nutrition, Setsunan University, Osaka 573-0101, JapanDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanDivision of Physical and Health Education, Setsunan University, Osaka 572-8508, JapanDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, JapanHepcidin-25 is suggested as a surrogate iron status marker in athletes who show exercise-induced anemia; however, the implications of hepcidin concentration in this population remain poorly understood. This study aimed to investigate the relationship between hepcidin and body fat levels in rugby football players. We included 40 male university rugby football players (RUG) and 40 non-athlete controls. All participants underwent an anthropometric analysis and blood testing that included both hepcidin-25 and ferritin levels. The hepcidin-25 level was slightly (11.6%, <i>p</i> = 0.50) higher, and the ferritin level was significantly (35.9%, <i>p</i> < 0.05) lower, in the RUG group than in controls. The hepcidin-25 to-ferritin ratio was significantly higher (62.5%, <i>p</i> < 0.05) in the RUG group. While significant U-shaped correlations were observed between the body fat and ferritin levels in both groups, the correlations between the hepcidin levels and fat mass index were significantly higher in the RUG group (RUG: <i>r</i> = 0.79, controls: <i>r</i> = 0.45). Notably, the RUG with the lower fat mass index group had a higher hepcidin-25 level, lower ferritin level, and then significantly higher hepcidin-25/ferritin ratio. The hepcidin-25/ferritin ratio may serve as a biomarker for iron status in RUG, especially RUG with lower fat mass.https://www.mdpi.com/2072-6643/13/9/2993hepcidin-25iron statusrugby football players |
| spellingShingle | Shinsuke Nirengi Mami Fujibayashi Sachiko Furuno Shin Sukino Akiko Suganuma Yaeko Kawaguchi Yasuharu Kawase Kazuhiko Kotani Naoki Sakane The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass Nutrients hepcidin-25 iron status rugby football players |
| title | The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass |
| title_full | The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass |
| title_fullStr | The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass |
| title_full_unstemmed | The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass |
| title_short | The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass |
| title_sort | hepcidin 25 ferritin ratio is increased in university rugby players with lower fat mass |
| topic | hepcidin-25 iron status rugby football players |
| url | https://www.mdpi.com/2072-6643/13/9/2993 |
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