Association of Systemic Comorbidities with Dry Eye Disease
We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/7/2040 |
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| author | Motoko Kawashima Masakazu Yamada Chika Shigeyasu Kazuhisa Suwaki Miki Uchino Yoshimune Hiratsuka Norihiko Yokoi Kazuo Tsubota for the DECS-J Study Group |
| author_facet | Motoko Kawashima Masakazu Yamada Chika Shigeyasu Kazuhisa Suwaki Miki Uchino Yoshimune Hiratsuka Norihiko Yokoi Kazuo Tsubota for the DECS-J Study Group |
| author_sort | Motoko Kawashima |
| collection | DOAJ |
| description | We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21–90] years). Ophthalmic examination findings included tear film break-up time (TBUT), Schirmer I value and keratoconjunctival staining score. QOL and health utility were evaluated using the Dry Eye-Related Quality-of-Life Score (DEQS) and Human Utility Index Mark 3 (HUI-3), respectively. Background information, including systemic comorbidities, was obtained. Prevalence of systemic comorbidities was 48.8% (219/449). No significant difference occurred between DEQS and systemic comorbidity. However, patients with dry eye disease and systemic comorbidities (depression and insomnia) exhibited significantly worse ocular surface parameters, particularly regarding TBUT, than those without. Dry eye disease with insomnia or depression comorbidity significantly correlated with friction-related diseases (including conjunctivochalasis or lid wiper epitheliopathy). A high prevalence of several systemic comorbidities occurred in patients with dry eye disease. This study shows an association between ocular signs and systemic comorbidities, particularly depression and insomnia. Ophthalmologists should be aware of patients’ systemic comorbidities in the diagnosis and management of dry eye disease. |
| first_indexed | 2024-03-10T18:48:16Z |
| format | Article |
| id | doaj.art-41d05758d6ac48d59e48925373d229f3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:48:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-41d05758d6ac48d59e48925373d229f32023-11-20T05:19:05ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0197204010.3390/jcm9072040Association of Systemic Comorbidities with Dry Eye DiseaseMotoko Kawashima0Masakazu Yamada1Chika Shigeyasu2Kazuhisa Suwaki3Miki Uchino4Yoshimune Hiratsuka5Norihiko Yokoi6Kazuo Tsubota7for the DECS-J Study GroupDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 1608582, JapanDepartment of Ophthalmology, Kyorin University School of Medicine, Tokyo 1818611, JapanDepartment of Ophthalmology, Kyorin University School of Medicine, Tokyo 1818611, JapanDepartment of Japan Medical Affairs, Santen Pharmaceutical Co., Ltd., Osaka 5308552, JapanDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 1608582, JapanDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo 1138431, JapanDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 6020841, JapanDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 1608582, JapanWe investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21–90] years). Ophthalmic examination findings included tear film break-up time (TBUT), Schirmer I value and keratoconjunctival staining score. QOL and health utility were evaluated using the Dry Eye-Related Quality-of-Life Score (DEQS) and Human Utility Index Mark 3 (HUI-3), respectively. Background information, including systemic comorbidities, was obtained. Prevalence of systemic comorbidities was 48.8% (219/449). No significant difference occurred between DEQS and systemic comorbidity. However, patients with dry eye disease and systemic comorbidities (depression and insomnia) exhibited significantly worse ocular surface parameters, particularly regarding TBUT, than those without. Dry eye disease with insomnia or depression comorbidity significantly correlated with friction-related diseases (including conjunctivochalasis or lid wiper epitheliopathy). A high prevalence of several systemic comorbidities occurred in patients with dry eye disease. This study shows an association between ocular signs and systemic comorbidities, particularly depression and insomnia. Ophthalmologists should be aware of patients’ systemic comorbidities in the diagnosis and management of dry eye disease.https://www.mdpi.com/2077-0383/9/7/2040cross-sectional studydry eye diseasesystemic comorbidity |
| spellingShingle | Motoko Kawashima Masakazu Yamada Chika Shigeyasu Kazuhisa Suwaki Miki Uchino Yoshimune Hiratsuka Norihiko Yokoi Kazuo Tsubota for the DECS-J Study Group Association of Systemic Comorbidities with Dry Eye Disease Journal of Clinical Medicine cross-sectional study dry eye disease systemic comorbidity |
| title | Association of Systemic Comorbidities with Dry Eye Disease |
| title_full | Association of Systemic Comorbidities with Dry Eye Disease |
| title_fullStr | Association of Systemic Comorbidities with Dry Eye Disease |
| title_full_unstemmed | Association of Systemic Comorbidities with Dry Eye Disease |
| title_short | Association of Systemic Comorbidities with Dry Eye Disease |
| title_sort | association of systemic comorbidities with dry eye disease |
| topic | cross-sectional study dry eye disease systemic comorbidity |
| url | https://www.mdpi.com/2077-0383/9/7/2040 |
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