Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

Fibroblast growth factor 1 (FGF1) is considered primarily as a ligand for FGF surface receptors (FGFRs) through which it activates a number of cellular responses. In addition to its canonical mode of action, FGF1 can act intracellularly, before secretion or after internalization and translocation fr...

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Bibliographic Details
Main Authors: Agata Lampart, Katarzyna Dominika Sluzalska, Aleksandra Czyrek, Aleksandra Szerszen, Jacek Otlewski, Antoni Wiedlocha, Malgorzata Zakrzewska
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
FGF1
translocation
intracellular FGF1
nuclear FGF
nuclear localization sequence
anti-apoptotic activity
Online Access:https://www.mdpi.com/2073-4409/11/3/522

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