Development of super-specific epigenome editing by targeted allele-specific DNA methylation

Development of super-specific epigenome editing by targeted allele-specific DNA methylation

Abstract Background Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation...

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Bibliographic Details
Main Authors: Nivethika Rajaram, Alexandra G. Kouroukli, Susanne Bens, Pavel Bashtrykov, Albert Jeltsch
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Epigenetics & Chromatin
Subjects:
Epigenome editing
Targeted DNA methylation
dCas9
DNMT3A/3L
Allele discrimination
Specificity
Online Access:https://doi.org/10.1186/s13072-023-00515-5

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