Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer
The contemporary comprehension of breast cancer has progressed to the molecular level. As a heterogeneous malignancy, conventional pathological diagnosis and histological classification could no longer meet the needs of precisely managing breast cancer. Genetic testing based on gene expression profi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/16607 |
| _version_ | 1797400101470076928 |
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| author | Tinglin Yang Wenhui Li Tao Huang Jun Zhou |
| author_facet | Tinglin Yang Wenhui Li Tao Huang Jun Zhou |
| author_sort | Tinglin Yang |
| collection | DOAJ |
| description | The contemporary comprehension of breast cancer has progressed to the molecular level. As a heterogeneous malignancy, conventional pathological diagnosis and histological classification could no longer meet the needs of precisely managing breast cancer. Genetic testing based on gene expression profiles and gene mutations has emerged and substantially contributed to the precise diagnosis and treatment of breast cancer. Multigene assays (MGAs) are explored for early-stage breast cancer patients, aiding the selection of adjuvant therapy and predicting prognosis. For metastatic breast cancer patients, testing specific genes indicates potentially effective antitumor agents. In this review, genetic testing in early-stage and metastatic breast cancer is summarized, as well as the advantages and challenges of genetic testing in breast cancer. |
| first_indexed | 2024-03-09T01:50:41Z |
| format | Article |
| id | doaj.art-41d2df51185146b783a614c87b8d5e2e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:50:41Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41d2df51185146b783a614c87b8d5e2e2023-12-08T15:16:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124231660710.3390/ijms242316607Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast CancerTinglin Yang0Wenhui Li1Tao Huang2Jun Zhou3Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaThe contemporary comprehension of breast cancer has progressed to the molecular level. As a heterogeneous malignancy, conventional pathological diagnosis and histological classification could no longer meet the needs of precisely managing breast cancer. Genetic testing based on gene expression profiles and gene mutations has emerged and substantially contributed to the precise diagnosis and treatment of breast cancer. Multigene assays (MGAs) are explored for early-stage breast cancer patients, aiding the selection of adjuvant therapy and predicting prognosis. For metastatic breast cancer patients, testing specific genes indicates potentially effective antitumor agents. In this review, genetic testing in early-stage and metastatic breast cancer is summarized, as well as the advantages and challenges of genetic testing in breast cancer.https://www.mdpi.com/1422-0067/24/23/16607breast cancerprecision diagnosistreatmentgenetic testingrisk assessment |
| spellingShingle | Tinglin Yang Wenhui Li Tao Huang Jun Zhou Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer International Journal of Molecular Sciences breast cancer precision diagnosis treatment genetic testing risk assessment |
| title | Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer |
| title_full | Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer |
| title_fullStr | Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer |
| title_full_unstemmed | Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer |
| title_short | Genetic Testing Enhances the Precision Diagnosis and Treatment of Breast Cancer |
| title_sort | genetic testing enhances the precision diagnosis and treatment of breast cancer |
| topic | breast cancer precision diagnosis treatment genetic testing risk assessment |
| url | https://www.mdpi.com/1422-0067/24/23/16607 |
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