Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies
Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbid...
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9896 |
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| author | Darya A. Kashatnikova Maryam B. Khadzhieva Dmitry S. Kolobkov Olesya B. Belopolskaya Tamara V. Smelaya Alesya S. Gracheva Ekaterina V. Kalinina Sergey S. Larin Artem N. Kuzovlev Lyubov E. Salnikova |
| author_facet | Darya A. Kashatnikova Maryam B. Khadzhieva Dmitry S. Kolobkov Olesya B. Belopolskaya Tamara V. Smelaya Alesya S. Gracheva Ekaterina V. Kalinina Sergey S. Larin Artem N. Kuzovlev Lyubov E. Salnikova |
| author_sort | Darya A. Kashatnikova |
| collection | DOAJ |
| description | Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbidities as well as to assess the host immune response measured by TREC/KREC levels in patients with pneumonia. The theoretical study was carried out using the Columbia Open Health Data (COHD) resource, which provides access to clinical concept prevalence and co-occurrence from electronic health records. The experimental study included TREC/KREC assays in young adults (18–40 years) with community-acquired (CAP) (<i>n</i> = 164) or nosocomial (NP) (<i>n</i> = 99) pneumonia and healthy controls (<i>n</i> = 170). Co-occurring rates between pneumonia, sepsis, acute respiratory distress syndrome (ARDS) and some other related conditions common in intensive care units were the top among 4170, 3382 and 963 comorbidities in pneumonia, sepsis and ARDS, respectively. CAP patients had higher TREC levels, while NP patients had lower TREC/KREC levels compared to controls. Low TREC and KREC levels were predictive for the development of NP, ARDS, sepsis and lethal outcome (<i>AUC<sub>TREC</sub></i> in the range 0.71–0.82, <i>AUC<sub>KREC</sub></i> in the range 0.67–0.74). TREC/KREC analysis can be considered as a potential prognostic test in patients with pneumonia. |
| first_indexed | 2024-03-10T01:44:05Z |
| format | Article |
| id | doaj.art-41d53bda31ca499cb741cf964f81a070 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:44:05Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41d53bda31ca499cb741cf964f81a0702023-11-23T13:19:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317989610.3390/ijms23179896Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental StudiesDarya A. Kashatnikova0Maryam B. Khadzhieva1Dmitry S. Kolobkov2Olesya B. Belopolskaya3Tamara V. Smelaya4Alesya S. Gracheva5Ekaterina V. Kalinina6Sergey S. Larin7Artem N. Kuzovlev8Lyubov E. Salnikova9The Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, RussiaThe Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, RussiaThe Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, RussiaThe Resource Center “Bio-Bank Center”, Research Park of St. Petersburg State University, St. Petersburg 199034, RussiaThe Laboratory of Clinical Pathophysiology of Critical Conditions, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow 107031, RussiaThe Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, RussiaThe Laboratory of Molecular Immunology, Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow 117198, RussiaThe Laboratory of Molecular Immunology, Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow 117198, RussiaThe Laboratory of Clinical Pathophysiology of Critical Conditions, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow 107031, RussiaThe Laboratory of Ecological Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, RussiaPneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbidities as well as to assess the host immune response measured by TREC/KREC levels in patients with pneumonia. The theoretical study was carried out using the Columbia Open Health Data (COHD) resource, which provides access to clinical concept prevalence and co-occurrence from electronic health records. The experimental study included TREC/KREC assays in young adults (18–40 years) with community-acquired (CAP) (<i>n</i> = 164) or nosocomial (NP) (<i>n</i> = 99) pneumonia and healthy controls (<i>n</i> = 170). Co-occurring rates between pneumonia, sepsis, acute respiratory distress syndrome (ARDS) and some other related conditions common in intensive care units were the top among 4170, 3382 and 963 comorbidities in pneumonia, sepsis and ARDS, respectively. CAP patients had higher TREC levels, while NP patients had lower TREC/KREC levels compared to controls. Low TREC and KREC levels were predictive for the development of NP, ARDS, sepsis and lethal outcome (<i>AUC<sub>TREC</sub></i> in the range 0.71–0.82, <i>AUC<sub>KREC</sub></i> in the range 0.67–0.74). TREC/KREC analysis can be considered as a potential prognostic test in patients with pneumonia.https://www.mdpi.com/1422-0067/23/17/9896pneumoniasepsisacute respiratory distress syndrome (ARDS)Columbia Open Health Data (COHD)comorbiditiesTREC/KREC |
| spellingShingle | Darya A. Kashatnikova Maryam B. Khadzhieva Dmitry S. Kolobkov Olesya B. Belopolskaya Tamara V. Smelaya Alesya S. Gracheva Ekaterina V. Kalinina Sergey S. Larin Artem N. Kuzovlev Lyubov E. Salnikova Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies International Journal of Molecular Sciences pneumonia sepsis acute respiratory distress syndrome (ARDS) Columbia Open Health Data (COHD) comorbidities TREC/KREC |
| title | Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies |
| title_full | Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies |
| title_fullStr | Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies |
| title_full_unstemmed | Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies |
| title_short | Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies |
| title_sort | pneumonia and related conditions in critically ill patients insights from basic and experimental studies |
| topic | pneumonia sepsis acute respiratory distress syndrome (ARDS) Columbia Open Health Data (COHD) comorbidities TREC/KREC |
| url | https://www.mdpi.com/1422-0067/23/17/9896 |
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