Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study
PurposeWe aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients.MethodsWe conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultras...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.900850/full |
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| author | Ursula Kahl Leah Schirren Yuanyuan Yu Susanne Lezius Marlene Fischer Marlene Fischer Maja Menke Christoph Sinning Axel Nierhaus Maren Vens Maren Vens Christian Zöllner Stefan Kluge Matthias S. Goepfert Matthias S. Goepfert Katharina Roeher |
| author_facet | Ursula Kahl Leah Schirren Yuanyuan Yu Susanne Lezius Marlene Fischer Marlene Fischer Maja Menke Christoph Sinning Axel Nierhaus Maren Vens Maren Vens Christian Zöllner Stefan Kluge Matthias S. Goepfert Matthias S. Goepfert Katharina Roeher |
| author_sort | Ursula Kahl |
| collection | DOAJ |
| description | PurposeWe aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients.MethodsWe conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultrasound examinations within the first 7 days after diagnosis of sepsis. We defined LVDD according to the 2016 recommendations of the American Society of Echocardiography and—for sensitivity analysis—according to an algorithm which has been validated in septic patients. We quantified pulmonary edema using the lung ultrasound score (LUSS), counting B-lines in four intercostal spaces.ResultsWe included 54 patients. LVDD was present in 51 (42%) of 122 echocardiography examinations. The mean (±SD) LUSS was 11 ± 6. There was no clinically meaningful association of LVDD with LUSS (B = 0.55 [95%CI: −1.38; 2.47]; p = 0.571). Pneumonia was significantly associated with higher LUSS (B = 4.42 [95%CI: 0.38; 8.5]; p = 0.033).ConclusionThe lack of a clinically meaningful association of LVDD with LUSS suggests that LVDD is not a major contributor to pulmonary edema in septic patients.Trial RegistrationNCT03768752, ClinicalTrials.gov, November 30th, 2018 - retrospectively registered. |
| first_indexed | 2024-12-12T07:13:29Z |
| format | Article |
| id | doaj.art-41d6c1b604074e358c876fa60acaf7cd |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T07:13:29Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-41d6c1b604074e358c876fa60acaf7cd2022-12-22T00:33:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.900850900850Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort StudyUrsula Kahl0Leah Schirren1Yuanyuan Yu2Susanne Lezius3Marlene Fischer4Marlene Fischer5Maja Menke6Christoph Sinning7Axel Nierhaus8Maren Vens9Maren Vens10Christian Zöllner11Stefan Kluge12Matthias S. Goepfert13Matthias S. Goepfert14Katharina Roeher15Klinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyInstitut für Medizinische Biometrie und Epidemiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik für Intensivmedizin Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Kardiologie Universitäres Herz- und Gefäßzentrum Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik für Intensivmedizin Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyInstitut für Medizinische Biometrie und Epidemiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyInstitut für Medizinische Biometrie und Statistik Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik für Intensivmedizin Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyKlinik für Anästhesie und Intensivmedizin Alexianer St. Hedwigkliniken Berlin, Berlin, GermanyKlinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, GermanyPurposeWe aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients.MethodsWe conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultrasound examinations within the first 7 days after diagnosis of sepsis. We defined LVDD according to the 2016 recommendations of the American Society of Echocardiography and—for sensitivity analysis—according to an algorithm which has been validated in septic patients. We quantified pulmonary edema using the lung ultrasound score (LUSS), counting B-lines in four intercostal spaces.ResultsWe included 54 patients. LVDD was present in 51 (42%) of 122 echocardiography examinations. The mean (±SD) LUSS was 11 ± 6. There was no clinically meaningful association of LVDD with LUSS (B = 0.55 [95%CI: −1.38; 2.47]; p = 0.571). Pneumonia was significantly associated with higher LUSS (B = 4.42 [95%CI: 0.38; 8.5]; p = 0.033).ConclusionThe lack of a clinically meaningful association of LVDD with LUSS suggests that LVDD is not a major contributor to pulmonary edema in septic patients.Trial RegistrationNCT03768752, ClinicalTrials.gov, November 30th, 2018 - retrospectively registered.https://www.frontiersin.org/articles/10.3389/fcvm.2022.900850/fulldiastolic dysfunctionlung edemaextravascular lung waterpneumoniaultrasoundechocardiography |
| spellingShingle | Ursula Kahl Leah Schirren Yuanyuan Yu Susanne Lezius Marlene Fischer Marlene Fischer Maja Menke Christoph Sinning Axel Nierhaus Maren Vens Maren Vens Christian Zöllner Stefan Kluge Matthias S. Goepfert Matthias S. Goepfert Katharina Roeher Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study Frontiers in Cardiovascular Medicine diastolic dysfunction lung edema extravascular lung water pneumonia ultrasound echocardiography |
| title | Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study |
| title_full | Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study |
| title_fullStr | Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study |
| title_full_unstemmed | Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study |
| title_short | Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study |
| title_sort | left ventricular diastolic dysfunction is not associated with pulmonary edema in septic patients a prospective observational cohort study |
| topic | diastolic dysfunction lung edema extravascular lung water pneumonia ultrasound echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.900850/full |
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