Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda
<p>Abstract</p> <p>Background</p> <p>Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because of several factors including poorer access to hydration therapy and greater prevalence o...
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| Format: | Article |
| Language: | English |
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BMC
2010-09-01
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| Series: | BMC Pediatrics |
| Online Access: | http://www.biomedcentral.com/1471-2431/10/69 |
| _version_ | 1818641416581021696 |
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| author | Mworozi Edison A Ndeezi Grace Wobudeya Eric Nakawesi Jane S Tumwine James K |
| author_facet | Mworozi Edison A Ndeezi Grace Wobudeya Eric Nakawesi Jane S Tumwine James K |
| author_sort | Mworozi Edison A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because of several factors including poorer access to hydration therapy and greater prevalence of malnutrition. Hitherto, the magnitude of rotavirus disease in Uganda has remained unknown. This study was therefore done to determine the prevalence and factors associated with rotavirus infection among children aged 3-59 months admitted with acute diarrhea to paediatric emergency ward of Mulago Hospital, Uganda</p> <p>Methods</p> <p>Three hundred and ninety children, aged between 3-59 months with acute diarrhoea were recruited. The clinical history, socio-demographic characteristics, physical examination findings and laboratory investigations were recorded. Stool samples were tested for rotavirus antigens using the DAKO IDEIA rotavirus EIA detection kit.</p> <p>Results</p> <p>The prevalence of rotavirus infection was 45.4%. On multivariate analysis rotavirus was significantly associated with a higher education (above secondary) level of the mother [OR 1.8; 95% CI 1.1-2.7]; dehydration [OR 1.8; 95% CI 1.1-3.0] and breastfeeding [OR 2.6; 95% CI 1.4-4.0]. Although age was significantly associated with rotavirus on bivariate analysis; this association disappeared on multivariate analysis. No significant association was found between rotavirus infection and nutritional status, HIV status and attendance of day care or school.</p> <p>Conclusions</p> <p>Rotavirus infection is highly prevalent among children with acute diarrhoea admitted to Mulago Hospital in Uganda.</p> |
| first_indexed | 2024-12-16T23:26:49Z |
| format | Article |
| id | doaj.art-41d7accdbb994ddcbd8c2ab70d26b5d8 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-16T23:26:49Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-41d7accdbb994ddcbd8c2ab70d26b5d82022-12-21T22:11:59ZengBMCBMC Pediatrics1471-24312010-09-011016910.1186/1471-2431-10-69Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in UgandaMworozi Edison ANdeezi GraceWobudeya EricNakawesi Jane STumwine James K<p>Abstract</p> <p>Background</p> <p>Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide. Children in developing countries die more because of several factors including poorer access to hydration therapy and greater prevalence of malnutrition. Hitherto, the magnitude of rotavirus disease in Uganda has remained unknown. This study was therefore done to determine the prevalence and factors associated with rotavirus infection among children aged 3-59 months admitted with acute diarrhea to paediatric emergency ward of Mulago Hospital, Uganda</p> <p>Methods</p> <p>Three hundred and ninety children, aged between 3-59 months with acute diarrhoea were recruited. The clinical history, socio-demographic characteristics, physical examination findings and laboratory investigations were recorded. Stool samples were tested for rotavirus antigens using the DAKO IDEIA rotavirus EIA detection kit.</p> <p>Results</p> <p>The prevalence of rotavirus infection was 45.4%. On multivariate analysis rotavirus was significantly associated with a higher education (above secondary) level of the mother [OR 1.8; 95% CI 1.1-2.7]; dehydration [OR 1.8; 95% CI 1.1-3.0] and breastfeeding [OR 2.6; 95% CI 1.4-4.0]. Although age was significantly associated with rotavirus on bivariate analysis; this association disappeared on multivariate analysis. No significant association was found between rotavirus infection and nutritional status, HIV status and attendance of day care or school.</p> <p>Conclusions</p> <p>Rotavirus infection is highly prevalent among children with acute diarrhoea admitted to Mulago Hospital in Uganda.</p>http://www.biomedcentral.com/1471-2431/10/69 |
| spellingShingle | Mworozi Edison A Ndeezi Grace Wobudeya Eric Nakawesi Jane S Tumwine James K Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda BMC Pediatrics |
| title | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| title_full | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| title_fullStr | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| title_full_unstemmed | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| title_short | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| title_sort | prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in uganda |
| url | http://www.biomedcentral.com/1471-2431/10/69 |
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