Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy
Abstract Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying normally grown and FGR fetuses in sh...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202203738 |
| _version_ | 1811235078334840832 |
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| author | Dimitra Flouri Jack R. T. Darby Stacey L. Holman Steven K. S. Cho Catherine G. Dimasi Sunthara R. Perumal Sebastien Ourselin Rosalind Aughwane Nada Mufti Christopher K. Macgowan Mike Seed Anna L. David Andrew Melbourne Janna L. Morrison |
| author_facet | Dimitra Flouri Jack R. T. Darby Stacey L. Holman Steven K. S. Cho Catherine G. Dimasi Sunthara R. Perumal Sebastien Ourselin Rosalind Aughwane Nada Mufti Christopher K. Macgowan Mike Seed Anna L. David Andrew Melbourne Janna L. Morrison |
| author_sort | Dimitra Flouri |
| collection | DOAJ |
| description | Abstract Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying normally grown and FGR fetuses in sheep and is then applied to humans. MRI scans are performed in pregnant ewes at 110 and 140 days (term = 150d) gestation and in pregnant women at 28+3 ± 2+5 weeks to measure feto‐placental SO2. Birth weight is collected and, in sheep, fetal blood SO2 is measured with a blood gas analyzer (BGA). Fetal arterial SO2 measured by BGA predicts fetal birth weight in sheep and distinguishes between fetuses that are normally grown, small for gestational age, and FGR. MRI feto‐placental SO2 in late gestation is related to fetal blood SO2 measured by BGA and body weight. In sheep, MRI feto‐placental SO2 in mid‐gestation is related to fetal SO2 later in gestation. MRI feto‐placental SO2 distinguishes between normally grown and FGR fetuses, as well as distinguishing FGR fetuses with and without normal Doppler in humans. Thus, a multi‐compartment placental MRI model detects low placental SO2 and distinguishes between small hypoxemic fetuses and normally grown fetuses. |
| first_indexed | 2024-04-12T11:46:00Z |
| format | Article |
| id | doaj.art-41d944f0f2624c8aa1881cb341321ea5 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T11:46:00Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-41d944f0f2624c8aa1881cb341321ea52022-12-22T03:34:22ZengWileyAdvanced Science2198-38442022-10-01930n/an/a10.1002/advs.202203738Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human PregnancyDimitra Flouri0Jack R. T. Darby1Stacey L. Holman2Steven K. S. Cho3Catherine G. Dimasi4Sunthara R. Perumal5Sebastien Ourselin6Rosalind Aughwane7Nada Mufti8Christopher K. Macgowan9Mike Seed10Anna L. David11Andrew Melbourne12Janna L. Morrison13School of Biomedical Engineering and Imaging Sciences King's College London London SE1 7EU UKEarly Origins of Adult Health Research Group Health and Biomedical Innovation UniSA Clinical and Health Sciences University of South Australia Adelaide SA 5001 AustraliaEarly Origins of Adult Health Research Group Health and Biomedical Innovation UniSA Clinical and Health Sciences University of South Australia Adelaide SA 5001 AustraliaEarly Origins of Adult Health Research Group Health and Biomedical Innovation UniSA Clinical and Health Sciences University of South Australia Adelaide SA 5001 AustraliaEarly Origins of Adult Health Research Group Health and Biomedical Innovation UniSA Clinical and Health Sciences University of South Australia Adelaide SA 5001 AustraliaSouth Australian Health & Medical Research Institute Preclinical Imaging & Research Laboratories Adelaide SA 5001 AustraliaSchool of Biomedical Engineering and Imaging Sciences King's College London London SE1 7EU UKDepartment of Medical Physics and Biomedical Engineering University College London London WC1E 6BT UKDepartment of Medical Physics and Biomedical Engineering University College London London WC1E 6BT UKDivision of Translational Medicine The Hospital for Sick Children University of Toronto Toronto ON M5G 1X8 CanadaDepartment of Paediatrics Division of Cardiology The Hospital for Sick Children University of Toronto Toronto ON M5G 1X8 CanadaElizabeth Garrett Anderson Institute for Women's Health University College London London WC1E 6AU UKSchool of Biomedical Engineering and Imaging Sciences King's College London London SE1 7EU UKEarly Origins of Adult Health Research Group Health and Biomedical Innovation UniSA Clinical and Health Sciences University of South Australia Adelaide SA 5001 AustraliaAbstract Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying normally grown and FGR fetuses in sheep and is then applied to humans. MRI scans are performed in pregnant ewes at 110 and 140 days (term = 150d) gestation and in pregnant women at 28+3 ± 2+5 weeks to measure feto‐placental SO2. Birth weight is collected and, in sheep, fetal blood SO2 is measured with a blood gas analyzer (BGA). Fetal arterial SO2 measured by BGA predicts fetal birth weight in sheep and distinguishes between fetuses that are normally grown, small for gestational age, and FGR. MRI feto‐placental SO2 in late gestation is related to fetal blood SO2 measured by BGA and body weight. In sheep, MRI feto‐placental SO2 in mid‐gestation is related to fetal SO2 later in gestation. MRI feto‐placental SO2 distinguishes between normally grown and FGR fetuses, as well as distinguishing FGR fetuses with and without normal Doppler in humans. Thus, a multi‐compartment placental MRI model detects low placental SO2 and distinguishes between small hypoxemic fetuses and normally grown fetuses.https://doi.org/10.1002/advs.202203738fetal developmentfetal growth restrictionfetal hypoxiaoxygenationplacental dysfunctionrelaxometry |
| spellingShingle | Dimitra Flouri Jack R. T. Darby Stacey L. Holman Steven K. S. Cho Catherine G. Dimasi Sunthara R. Perumal Sebastien Ourselin Rosalind Aughwane Nada Mufti Christopher K. Macgowan Mike Seed Anna L. David Andrew Melbourne Janna L. Morrison Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy Advanced Science fetal development fetal growth restriction fetal hypoxia oxygenation placental dysfunction relaxometry |
| title | Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy |
| title_full | Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy |
| title_fullStr | Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy |
| title_full_unstemmed | Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy |
| title_short | Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy |
| title_sort | placental mri predicts fetal oxygenation and growth rates in sheep and human pregnancy |
| topic | fetal development fetal growth restriction fetal hypoxia oxygenation placental dysfunction relaxometry |
| url | https://doi.org/10.1002/advs.202203738 |
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